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Pharm week > Adrenergic Drugs (Konorev) > Flashcards

Adrenergic Drugs (Konorev) Flashcards

1
Q 
What G proteins are associated with:
a1
a2
B
D1
D2
A

a1:Gq
a2:Gi
B:Gs
D1: Gs
D2:Gi

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2
Q

What is the difference between direct and indirect-acting adrenergic drugs?

A

Direct-acting produce their effects via direct interaction with adrenergic receptors

Indirect-acting produce their effects by increasing or reducing the concentration of norepinephrine at target receptors

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3
Q

Phenylephrine

A

An alpha agonist
a1>a2»»>B

effective mydriatic and decongestant
Causes severe vasoconstriction, bp elevation, and severe bradycardia

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4
Q

Clonidine

A

selective a2 agonist
a2>a1»»>B

Decreasing sympathetic outflow
Reduction in bp
bradycardia

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5
Q

Norepinephrine

A

a1=a2 ; B1»B2
Potent cardiac stimulant but reduces heart rate
Potent vasoconstrictor
No B2 agonist effects - no bronchodilation and vasodilation
Increases peripheral vascular resistance and bp

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6
Q

Isoproterenol

A

B1=B2&raquo_space;»>a
non-selective beta agonist
positive inotropic and chronotropic action, increases CO (B1)

Vasodilator, decreases arterial pressure (B2)

causes bronchodilation (B2)

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7
Q

Dobutamine

A

B1>B2, a1
selective B1 agonist
Potent inotropic action

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8
Q

Albuterol

A

B2>B1»»a

selective B2 agonist
causes bronchodilation

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9
Q

What does cocaine inhibit?

A

Dopamine and NE re-uptake

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10
Q

What are the inhibitors of monoaminoxidase (MAO)?

A

Phenelzine

Selegiline

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11
Q

What are the inhibitors of monoaminoxidase (MAO)?

A

Phenelzine

Selegiline

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12
Q

What are the indirect sympathomimetics that increase release of dopamine and NE and inhibit their re-uptake?

A

Amphetamines
Methylphenidate
Tyramine

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13
Q

What increases the release of dopamine and NE and is a direct receptor agonist

A

ephedrine

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14
Q

Indirect-acting adrenomimetics stuff

A

Usually more lipophilic compounds
Easily penetrate the BBB (except tyramine)
CNS stimulants
Heavily abused drugs
Tyramine is a product of decarboxylation of tyrosine

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15
Q

Which drugs are used for hypotensive emergencies

A

Norepinephrine, phenylephrine

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16
Q

What adrenomimetic is used to treat chronic hypotension

A

ephedrine

17
Q

What adrenomimetic is used to treat cardiogenic shock

A

dobutamine

18
Q

What is used to treat heart failure

A

Short term use of dobutamine in acute HF

19
Q

What is used to treat hypertension

A

alpha 2 agonists for the long term treatment

20
Q

What is the emergency thereapy for complete AV block and cardiac arrest

A

Epinephrine, isoproterenol

21
Q

What is the emergency therapy for complete AV block and cardiac arrest

A

Epinephrine, isoproterenol

22
Q

What is used to treat depression

A

phenelzine, selegiline

23
Q

What is used to treat narcolepsy

A

Amphetamines, methylphenidate

24
Q

What is used to treat obesity

A

Ephedrine, amphetamines

25
Q

What is used to treat bronchial asthma

A

albuterol

26
Q

What is used for decongestion of mucous membrane

A

phenylephrine, ephedrine

27
Q

What is used to treat anaphylaxis

A

Epinephrine (used for both respiratory and cardiovascular components)

28
Q

What is used for examination of the retina (induction of mydriasis

A

phenylephrine

29
Q

What is used to treat glaucoma

A

alpha 2 selective agonists

30
Q

What is used to treat stress urinary incontinence

A

ephedrine

31
Q

Cardiovascular adverse effects of adrenomimetics

A

Elevation in bp
Increased cardiac work may precipitate myocardial ischemia and HF
Sinus tachycardia and serious ventricular arrhythmias, may induce sudden cardiac death

32
Q

Central nervous system toxicity from adrenomimetics

A 
insomnia
lack of appetite
anxiety, restlessness
psychoses
convulsions and hemorrhagic stroke (cocaine)

Pharm week (9 decks)

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