Adrenergic Drugs (Konorev) Flashcards
What G proteins are associated with: a1 a2 B D1 D2
a1:Gq
a2:Gi
B:Gs
D1: Gs
D2:Gi
What is the difference between direct and indirect-acting adrenergic drugs?
Direct-acting produce their effects via direct interaction with adrenergic receptors
Indirect-acting produce their effects by increasing or reducing the concentration of norepinephrine at target receptors
Phenylephrine
An alpha agonist
a1>a2»»>B
effective mydriatic and decongestant
Causes severe vasoconstriction, bp elevation, and severe bradycardia
Clonidine
selective a2 agonist
a2>a1»»>B
Decreasing sympathetic outflow
Reduction in bp
bradycardia
Norepinephrine
a1=a2 ; B1»B2
Potent cardiac stimulant but reduces heart rate
Potent vasoconstrictor
No B2 agonist effects - no bronchodilation and vasodilation
Increases peripheral vascular resistance and bp
Isoproterenol
B1=B2»_space;»>a
non-selective beta agonist
positive inotropic and chronotropic action, increases CO (B1)
Vasodilator, decreases arterial pressure (B2)
causes bronchodilation (B2)
Dobutamine
B1>B2, a1
selective B1 agonist
Potent inotropic action
Albuterol
B2>B1»»a
selective B2 agonist
causes bronchodilation
What does cocaine inhibit?
Dopamine and NE re-uptake
What are the inhibitors of monoaminoxidase (MAO)?
Phenelzine
Selegiline
What are the inhibitors of monoaminoxidase (MAO)?
Phenelzine
Selegiline
What are the indirect sympathomimetics that increase release of dopamine and NE and inhibit their re-uptake?
Amphetamines
Methylphenidate
Tyramine
What increases the release of dopamine and NE and is a direct receptor agonist
ephedrine
Indirect-acting adrenomimetics stuff
Usually more lipophilic compounds
Easily penetrate the BBB (except tyramine)
CNS stimulants
Heavily abused drugs
Tyramine is a product of decarboxylation of tyrosine
Which drugs are used for hypotensive emergencies
Norepinephrine, phenylephrine
What adrenomimetic is used to treat chronic hypotension
ephedrine
What adrenomimetic is used to treat cardiogenic shock
dobutamine
What is used to treat heart failure
Short term use of dobutamine in acute HF
What is used to treat hypertension
alpha 2 agonists for the long term treatment
What is the emergency thereapy for complete AV block and cardiac arrest
Epinephrine, isoproterenol
What is the emergency therapy for complete AV block and cardiac arrest
Epinephrine, isoproterenol
What is used to treat depression
phenelzine, selegiline
What is used to treat narcolepsy
Amphetamines, methylphenidate
What is used to treat obesity
Ephedrine, amphetamines
