Adrenergic drugs Flashcards
An alpha and beta agonist used as a DOC for anaphylactic shock, cardiac arrest, and partnered with local anesthetics. It also has more beta-receptor activity
Epinephrine
An alpha and beta agonist used as a drug of choice for septic shock. It has more alpha activity, resulting to greater vasoconstriction than epinephrine
Norepinephrine
An alpha and beta agonist. At high doses, it has alpha activity. At moderate doses, it has beta activity. At low doses, it has dopaminergic activity
Dopamine
An alpha-1 agonist that is used as a nasal decongestant, shock, and mydriatic. It has a side effect of rhinitis medicamentosa, which is why it is suggested that this drug should be taken not more than 3 days
Phenylephrine
Alpha-1 agonists used as nasal decongestant
Phenylpropanolamine
Pseudoephedrine
An alpha-1 agonist used as treatment for hypotension
Methoxamine
Alpha-2 agonists used as treatment for hypertension
One drug is hepatotoxic and is positive for Coomb’s test
One of the alpha-2 agonist used for hypertensive urgency
Clonidine, Methyldopa, Guanfacine, Guanabenz
Methyldopa
Clonidine
An alpha-1 and -2 agonist used as an OTC nasal spray decongestant
Oxymetazoline
A beta-1 agonist used as a DOC for cardiogenic shock
Dobutamine
Beta-2 agonists used for asthma
SABA: Albuterol/ Salbutamol, Terbutaline, Metaproterenol
LABA: Salmeterol, Formoterol
A beta-2 agonist that has an off-label indication, which is for premature labor, acting as a tocolytic
Terbutaline
A beta- 1 and -2 agonist used for cardiac arrest, but used rarely for asthma
Isoproterenol
An indirect acting agonist found in red wine, beer, cheese, and chocolates. It can cause hypertension in patients taking MAO inhibitors, resulting in the “cheese effect”
Tyramine
Indirect acting agonists used for ADHD, anorexiant, and management for narcolepsy
Methylphenidate
Amphetamine
Phentermine
A mixed direct and indirect agonist which is an alkaloid, coming from Ma Huang (Ephedra sinica). It is used for urinary incontinence, bronchospasm, hypotension, nasal congestion, and narcolepsy
Ephedrine
A mixed direct and indirect acting agonist that is used for hypotension
Metaraminol
Alpha-1 antagonists used for HTN and BPH. However, it has a side effect of orthostatic hypotension due to the first dose. A remedy for this side effect is to adjust the first dose to 1/3 or 1/4 of normal dose
Tamsulosin
Doxazosin
Prazosin
Terazosin
An alpha-2 antagonist that is used for impotence as penile injection
Yohimbine
An alpha-1 and -2 antagonist that is irreversible and long-acting for treatment of hypertension caused by pheochromocytoma, which is a tumor in the adrenal medulla, and also for Raynaud disease
Phenoxybenzamine
An alpha-1 and -2 antagonist that is reversible and short-acting for treatment of hypertension caused by pheochromocytoma, which is a tumor in the adrenal medulla
Phentolamine
It is a nonselective beta antagonist used for HTN, post-MI, angina pectoris, SVT, and heart failure, known for having the longest half-life among all beta blockers
Nadolol
It is a nonselective beta antagonist used for HTN, post-MI, angina pectoris, SVT, and heart failure
Sotalol
It is a nonselective beta antagonist used for HTN, post-MI, angina pectoris, SVT, and heart failure. Aside from these indications, it is also used for treating glaucoma
Timolol
It is a nonselective beta antagonist used for HTN, post-MI, angina pectoris, SVT, and heart failure that is known to be the prototype for beta adrenergic antagonist. It is has an off-label use for migraine, stage fright, and hyperthyroidism
Propranolol
They are selective beta-1 antagonists that are indicated for hypertensive patients with impaired pulmonary function
This is the most cardio-selective of all selective beta-1 antagonists
The beta-blocker with the shortest half-life
Celiprolol, Nebivolol, Bisoprolol, Betaxolol, Esmolol, Acebutolol, Atenolol, Metoprolol
Nebivolol
Esmolol
They are partial beta agonists with intrinsic sympathetic activity, which allows lessening of risks of hypotension and bradycardia
Acebutolol
Celiprolol
Penbutolol
Pindolol
Labetalol
Carteolol
They are combined alpha and beta antagonists used for hypertensive patients with increased peripheral vascular resistance due to alpha blockade
One of the combined antagonists used for pregnancy-induced hypertension. This drug is also used for hypertensive emergency
Labetalol
Carvedilol
Labetalol
A drug used to inhibit NE synthesis by inhibiting the formation of L-DOPA through the inhibition of tyrosine hydroxylase
Metyrosine
A drug used to inhibit the dopamine storage or acts as a VMAT blocker
Reserpine
These are drugs used to inhibit NE release
Guanethidine
Guanadrel
Bretylium
These are drugs used to inhibit the NE reuptake for indications that have problems regarding inadequate NE
Cocaine
TCAs
Reboxetine
