Adrenergic agonists Flashcards
What are examples of selective beta-2 adrenergic agonists?
Metaproterenol
Terbutaline
Albuterol
Salmeterol
What is the mechanism of action of selective beta-2 adrenergic agonists?
Stimulates β-adrenergic receptors and production of cAMP –> bronchial smooth muscle relaxation and inhibition of release of inflammatory mediators from mast cells in airways –> decreased airway resistance
Should M, T, or A be given to a patient with tachycardia?
No…they can be cardio-stiumulatory (tachycardia and/or HTN)
What can happen if a patient takes high doses of selective beta-2 adrenergic agonists?
CNS stimulation (nervousness, tremors)
Which drug will also stimulate airway epithelial ciliary function?
Salmeterol
Which selective beta-2 adrenergic agonists should not be used by pregnant/breast-feeding women?
Albuterol
Terbutaline
Which selective beta-2 adrenergic agonists cannot be given alone and is contraindicated in multiple other lung conditions?
Salmeterol
What are examples of alpha-adrenergic agonists?
Phenylephrine
Pseudoephedrine
How does phenylephrine help with asthma?
Constriction of arterioles –> decongestion (decreases cAMP via inhibition of adenyl cyclase)
Which alpha-adrenergic agonists is more likely to cross BBB and placenta and distribute to breast milk?
Pseudophedrine
Which alpha-adrenergic agonist is metabolized in the intestinal wall?
Phenylephrine
Where are alpha-adrenergic agonists excreted?
Urine…pee…piss
What is a side effect of pseudophedrine that isn’t a side effect of phenylephrine?
CNS stimulation/anxiety
What is a side effect common to both alpha-adrenergic agonists?
HTN or VTach
Can alpha-adrenergic agonists be used with anesthetics the same way that epinephrine can?
NO…heck no…fuck no
