Adrenaline

Question 1

What drug class is adrenaline

Answer 1

Sympathomimetic

Question 2

Pharmacology of adrenaline

Answer 2

Naturally occurring catecholamine which acts on A1, B1, B2 receptions.
A1- Peripheral vasoconstriction
B1- Increase in HR and force on myocardial contraction = increase in irritability of the ventricles.
B2- bronchodilation

Question 3

Presentation of adrenaline

Answer 3

1:1000 (1mg/1ml)
1:10,000 (1mg/10ml)
300microg epipen
150microg epipen

Question 4

Indications for adrenaline

Answer 4

• Cardiac arrest
• Anaphylaxis / severe allergic reaction
• Severe-life threatening brochospasm/ silent chest.
• Shock unresponsive to adequate fluid resus.
• Croup.

Question 5

Contraindications for Adrenaline

Answer 5

Nil

Question 6

Side effects for adrenaline

Answer 6

Anxiety
Hypertension
Palpitations/ tachyarrythmias
Pupil dilation
Tremor

Question 7

Dosage of adrenaline

Answer 7

Cardiac arrest:
IV- 1mg every 3-5 mins, no max dose

Analphylaxis
IM- 300microg Epipen
IM- 500microgs, every 5 mins, no max dose

Severe life threatening bronchospasm/ silent chest:
IM- 500microg every 5 mins no max

Croup:
Neb- 5mg single dose only