adrenal glands Flashcards
Where is the adrenal gland located?
On the top of each kidney
What are the two main parts of the adrenal gland?
Cortex and medulla
What are the three zones of the adrenal cortex?
- Zona glomerulosa
- Zona fasciculata
- Zona reticularis
What does the zona glomerulosa produce?
Mineralocorticoids
What is the primary mineralocorticoid produced by the adrenal gland?
Aldosterone
What stimulates the release of aldosterone?
- ACTH
- Renin-Angiotensin System
- [K+] blood
What condition results from excess aldosterone?
Hyperaldosteronism
What condition results from deficient aldosterone?
Hypoaldosteronism or Addison’s disease
What is the function of the Renin-Angiotensin-Aldosterone System?
Regulates blood volume, electrolyte balance, and vascular resistance
What cells in the renal tubules are involved in the Renin-Angiotensin-Aldosterone System?
Juxtaglomerular cells (Macula Densa)
What is the role of angiotensin II?
Vasoconstrictor
What triggers renin release?
Reduction in blood volume and blood pressure
What is the effect of aldosterone on sodium?
Stimulates reabsorption of Na+
What is the role of principal cells in the kidneys?
Stimulate countercurrent Na+-K+ exchange
What is the effect of aldosterone on potassium?
Increased K+ excreted in urine
What does cortisol primarily regulate?
Metabolism and stress response
What is the primary glucocorticoid produced by the adrenal gland?
Cortisol
What condition results from excess cortisol?
Cushing’s Syndrome
What condition results from deficient cortisol?
Addison’s disease
What type of hormone is cortisol considered?
Catabolic hormone
What is the cortisol awakening response?
Diurnal circadian rhythm
What hormones do the zona fasciculata and reticularis synthesize?
Adrenal androgens
Which hormone is produced principally by the adrenal medulla?
Adrenaline
What is the primary function of adrenaline?
Stress response (‘Fight-or-Flight’)
What effects does adrenaline have on the body?
- Increases heart rate
- Increases force of myocardial contraction
- Reduces gastrointestinal motility
- Increases blood pressure
- Causes bronchodilation
- Increases rate of breathing
- Causes vasoconstriction in skin and GIT
- Causes vasodilation in muscles, heart, and liver
- Promotes glycogenolysis and lipolysis
Fill in the blank: The adrenal medulla produces principally _______.
Adrenaline
What is the precursor to adrenaline in its synthesis pathway?
Tyrosine
What is the role of ACTH in adrenal hormone production?
Stimulates production of adrenal hormones
Where is the adrenal gland located?
On the top of each kidney
What are the two main parts of the adrenal gland?
Cortex and medulla
What are the three zones of the adrenal cortex?
- Zona glomerulosa
- Zona fasciculata
- Zona reticularis
What does the zona glomerulosa produce?
Mineralocorticoids
What is the primary mineralocorticoid produced by the adrenal gland?
Aldosterone
What stimulates the release of aldosterone?
- ACTH
- Renin-Angiotensin System
- [K+] blood
What condition results from excess aldosterone?
Hyperaldosteronism
What condition results from deficient aldosterone?
Hypoaldosteronism or Addison’s disease
What is the function of the Renin-Angiotensin-Aldosterone System?
Regulates blood volume, electrolyte balance, and vascular resistance
What cells in the renal tubules are involved in the Renin-Angiotensin-Aldosterone System?
Juxtaglomerular cells (Macula Densa)
What is the role of angiotensin II?
Vasoconstrictor
What triggers renin release?
Reduction in blood volume and blood pressure
What is the effect of aldosterone on sodium?
Stimulates reabsorption of Na+
What is the role of principal cells in the kidneys?
Stimulate countercurrent Na+-K+ exchange
What is the effect of aldosterone on potassium?
Increased K+ excreted in urine
What does cortisol primarily regulate?
Metabolism and stress response
What is the primary glucocorticoid produced by the adrenal gland?
Cortisol
What condition results from excess cortisol?
Cushing’s Syndrome
What condition results from deficient cortisol?
Addison’s disease
What type of hormone is cortisol considered?
Catabolic hormone
What is the cortisol awakening response?
Diurnal circadian rhythm
What hormones do the zona fasciculata and reticularis synthesize?
Adrenal androgens
Which hormone is produced principally by the adrenal medulla?
Adrenaline
What is the primary function of adrenaline?
Stress response (‘Fight-or-Flight’)
What effects does adrenaline have on the body?
- Increases heart rate
- Increases force of myocardial contraction
- Reduces gastrointestinal motility
- Increases blood pressure
- Causes bronchodilation
- Increases rate of breathing
- Causes vasoconstriction in skin and GIT
- Causes vasodilation in muscles, heart, and liver
- Promotes glycogenolysis and lipolysis
Fill in the blank: The adrenal medulla produces principally _______.
Adrenaline
What is the precursor to adrenaline in its synthesis pathway?
Tyrosine
What is the role of ACTH in adrenal hormone production?
Stimulates production of adrenal hormones