Adrenal Diseases Flashcards
also known as suprarenal gland, small triangular shapes gland located on the top of the both kidneys. 4-5 grams in weight.
Adrenal Gland
is the outermost region of the adrenal cortex and is the only zone of the adrenal gland that contains the enzyme aldosterone synthase (CYP11B2)
Zona Glomerulosa
the middle zone of the adrenal cortex secretes glucocorticoids which are important for carbohydrate, protein and lipid metabolism. (Regulates blood sugar)
Zona Fasiculata
produces androgens (sex hormones)
Zona Reticularis
ZG: Mineralocorticoids
Aldosterone
ZF: Glucocorticoids
Cortisol
Prednisone
ZR: Sex Hormones
Androgen
Estrogen
Adrenal Medulla releases ?
Cathecolamines
AM: Cathecolamines
Norepinephrine
Epinephrine
Dopamine
Hyposecretion of Aldosterone & Cortisol
Addison’s Disease
Addison’s Cause: Primary adrenal insufficiency?
Hyposecretion of adrenal cortex hormone
Mineralocorticoids
Glucocorticoids
Androgens
Autoimmune
Addison’s Cause: Secondary adrenal insufficiency?
Hyposecretion of adrenal cortex hormones
Hyposecretion of ACTH from anterior pituitary gland
Mineralocorticoids release is spared
Addison’s CM: Sugar and Salt Levels?
Hypoglycemia
Hyponatremia
Addison’s CM: Tired and Muscle?
Weakness
Addison’s CM: Reproductive Organs in Fm and M?
Irregular Menstrual Cycle
Erectile Dysfunction
Addison’s CM: Electrolyte Levels Increase?
Hyperkalemia
Hypercalcemia
Addison’s CM: Skin?
Hyperpigmentation (Bronze-like)
Addison’s CM: Gastrointestinal Disturbance?
Diarrhea
Addison’s CM: Emotional Disturbance?
Depression
Addison’s CM: Blood Pressure?
Hypotension
Addison’s Intervention: Monitor for?
Glucose, K+, Na+, Ca+ Levels
VS
I and O
Weight
Addison’s CM: Weight?
Loss
Addison’s Intervention: Hormone Replacement Therapy?
Mineralocorticoid: Fludrocortisone (florinef)
Glucocorticoid: Prednisone, Hydrocortisone
Addison’s Intervention: Diet?
High CHO and CHON, enought salt
Addison’s Intervention: When taking glucocorticoids?
Calcium and Vitamin D supplements
Addison’s Intervention: Glucocorticoids needa to be increased when?
Stress, Illness, Surgery
Addison’s Intervention: Avoid?
Illness, Stress, Strenous Activities
the patient has extremely LOW CORTISOL levels (life threatening)
Addisonian Crisis
Addisonian Crisis 5s
Sudden pain in stomach, back, legs
Syncope (unconcious)
Shock
Super Low BP
Severe vomiting, diarrhea, headache
Addisonian Crisis Intervention
IV Cortisol Stat ( Solu-Cortef and D5NS)
caused by increased amounts of ACTH secreted by the pituitary gland
Cushing’s Disease
is a metabolic disorder characterized by abnormally increased secretion (endogenous) of cortisol
Cushing’s Disease
caused by an outside cause or medical treatment such as glucocorticoid therapy
Cushing’s Syndrome
hyper-secretion of CORTISOL
Cushing’s Disease
Cushing’s CM: Fragile ? that easily bruises
Skin
Ecchymosis
Cushing’s CM: Truncal ? with ?
Obesity, Small Arms
Cushing’s CM: face? , Dorsocervical?
Rounded, Moon face
Fat, Buffalo hump
Cushing’s CM: Reproductice Issues in Fm and M?
Amenorrhea, Hirsutism
Erectile Dysfunction
Cushing’s CM: Blood Sugar Levels?
Hyperglycemia
Cushing’s CM: Electrolyte Levels
Hypernatremia
Hypokalemia, Hypocalcemia
Cushing’s CM: Blood Pressure?
Hypertension
Cushing’s CM: Red-purplish ? on ?
Striae
Abdomen, Back, and Thighs
Cushing’s CM: General ? and ? wasting
Weakness
Muscle
Cushing’s Intervention: Prepare patient for ? to remove the pituitary tumor
Hypophysectomy
Cushing’s Intervention: Prepare the client for ? if the condition results from an adrenal adenoma
Adrenalectomy
Cushing’s Intervention: ? may be required following
adrenalectomy
Glucocorticoid Replacement
Cushing’s Intervention: Diet?
Low Calorie, Sodium
High CHON, K+, Ca+
Vitamin Supplements
Cushing’s DT: Measures the response of adrenal glands to ACTH. Dexamethasone ?mg is given ? at ?pm.
Dexamethasone Suppression Test (Confirmatory Test)
Oral, 1mg, 11pm
Cushing’s DT: It decreases in the evening- during early phase of
sleep
Plasma Cortisol 10-20 mcg/dl
Cushing’s MM: to decrease production of glucocorticoids
Mitotane (Lysodren)
Cushing’s MM: Cortisol Receptor blocker
Korlym (Mifepristone)
hypersecretion of mineralocorticoids
(aldosterone) from the adrenal cortex of the adrenal gland
Hyperaldosteronism/Conn’s Syndrome
Seen more frequently in women (30-50 y/o)
Cause by a tumor or hyperplasia of adrenal gland
Hyperaldosteronism/Conn’s Syndrome
Seen more frequently in women (30-50 y/o)
Cause by a tumor or hyperplasia of adrenal gland
Hyperaldosteronism/Conn’s Syndrome
Conn’s CM: Electrolyte Levels
Hypernatremia
Hypokalemia
Conn’s CM: ABG Analysis
Metabolic Alkalosis
Conn’s CM: Cardiac ?
Dysrhythmias
Conn’s DT: in supine position with normal
sodium diet
? , with upright /standing position or seated for at least ? is 2-5x supine value
Plasma Aldosterone
2-9 ng/dl or 55-250 pmol/L
2hrs
Conn’s DT: Urine Aldosterone
14-16 nmol/24hrs
Conn’s CM: 2P
Polyuria
Polydipsia
Conn’s Triad
Hypertension, Hypokalemia, Metabolic Alkalosis
Conn’s Intervention: Monitor
VS
I and O
Urine Specific Gravity
Signs of Hypernatremia, Hypokalemia
Conn’s Intervention: Maintain ? restriction as ordered
Sodium
Conn’s Intervention: Administer ? and ?
supplements as ordered
Spironolactone (Aldactone)
Potassium
Conn’s Intervention: Prepare the client for an ? if indicated
Adrenalectomy
Conn’s Intervention: Health teaching after adrenalectomy
Glucocorticoid Replacement
Catecholamine-producing tumor usually
found in the adrenal medulla, but extraadrenal locations include the chest, bladder, abdomen, and brain
Pheochromocytoma
Excessive amounts of E and NE are secreted
Pheochromocytoma
founds in the adrenal medulla and secrete catecholamines
Chromaffin Cells
Pheo CM: Face ?, Heart ?
Flushing
Palpitations
Pheo CM: Increases?
BP, HR
Glucose (Hyperglycemia)
Anxiety, Fear
Pheo CM: Severe ?, Pain in ? with ?
Headaches
Chest and Abdomen with NV
Pheo CM: ? Intolerance, Profuse ?
Heat
Diaphoresis
Pheo CM: ? Loss, Tired and ?
Weight
Weak
Pheo can be triggered by eating ? and medications such as ?
Tyramine rich foods
MAOIs
Occurs most commonly between ages 25-50, hereditary in some cases
Pheochromocytoma
Pheo DT: is produced in the liver and is a major product of epinephrine and norepinephrine
metabolism which is excreted in the urine
Vanillyl Mandelic Acid (VMA)
Pheo DT: Preparation - No food and fluid with ? for ? hours before the test
- Normal level mg/24 hours
Coffee, Tea, Cocoa, Chocolate
48 hrs
2-7 mg
Pheo Intervention: Monitor closely ?
VS - BP and HR
Hypertensive Crisis
Glucose
Pheo Intervention: Instruct the client not to ?, drink ?-containing beverages, or change ? suddenly.
Smoke
Caffeine
Position
Pheo Intervention: Provide care for the client with an ? as ordered
Adrenalectomy
Pheo Intervention: Administer pre-opt ? (Cardura, Minipress, Hyrtin): work by blocking noradrenaline, reduces catecholamines
Alpha-adrenergic blockers
Pheo Intervention: may also be prescribe patient a ? like ? or ? to help with hypertension and tachycardia
Beta-adrenergic Blockers (Labetalol or Inderal)
Pheo Intervention: If patient is having a bilateral adrenalectomy (both glands removed ) - will have to take ? and ? for
Glucocorticoids, Mineralocorticoids
Lifetime
Pheo Intervention: If patient is having a unilateral adrenalectomy (only one gland removed): will have to take ? for approximately ?
Glucocorticoids
2 Years
Pheo Intervention: Diet
High Calorie