adrenal 2 : cushings Flashcards
1
Q
Cushing syndrome
A
any excess cortisol state
2
Q
Cushing’s Syndrome due to ACTH-producing pituitary adenoma
A
cushings disease
3
Q
clinical features of cushings syndrome
A
glucocorticoid excess (hypercortisolism), mineralocorticoid excess, androgen excess
4
Q
clinical features of androgen excess
A
hirsutism, acne, amenorrhea
5
Q
signs of glucocorticoid excess (hypercortisolism)
A
Muscle wasting, weakness Easy bruising, poor wound healing Osteoporosis, fractures Central obesity Glucose intolerance, hyperglycemia, diabetes psychiatric disturbances
6
Q
signs of mineralocorticoid excess
A
salt retention, hypertension, edema, hypokalemia, metabolic alkalosis
7
Q
tests used to confirm hypercortisolism
A
- 24 hr urinary free cortisol
- low dose demethasone suppression test LDDST
- salivary free cortisol
8
Q
Contralateral gland____ due to decreased ACTH in adrenal cushings syndrome
A
atrophic
9
Q
in the HDDST - Pituitary ACTH production will respond ______ after high-dose dexamethasone, but ectopic ACTH production will ____
A
- decrease
- increase
