Adipose Tissue

Question 1

What is adipose tissue?

Answer 1

loose CT populated by lipid accumulating adipocytes

Question 2

What are the 2 types of adipose tissue?

Answer 2

Brown and White

Question 3

What % of weight is from white adipose tissue (WAT)?

Answer 3

20-25%

Question 4

What is the role of WAT?

Answer 4

Triglyceride storage
Structural
Insulator
Protection

Question 5

What is the name of the hormones secreted by adipose tissue?

Answer 5

Adipokines

Question 6

What type of hormone is leptin?

Answer 6

Anorexigenic

Question 7

Where does leptin act?

Answer 7

Receptors in hypothalamus

Question 8

What is the function of BAT?

Answer 8

Generate heat

Question 9

What causes Gaucher disease?

Answer 9

Deficiency in enzyme glucocerebrosidase- acts on glucosylceramide. Glucosylceramide accumulates in macrophages.

Question 10

What is fat stored as and what is it derived from?

Answer 10

Stored as triglycerides.

Derived from lipoproteins and glucose.

Question 11

How does leptin control appetite?

Answer 11

Higher leptin suppresses appetite

Lower leptin increases appetite.

Question 12

Whats the difference between BAT and WAT at the cellular level?

Answer 12

BAT is multilocular

WAT is unilocular

Question 13

Outline non-shivering (chemical) thermogenesis

Answer 13

1. Increase in metabolic heat production independent of muscle contraction
2. Sympathetic nervous system stims BAT
3. Important in newborns (cannot shiver)

Question 14

How is Gaucher disease treated?

Answer 14

Enzyme replacement therapy (ERT)

Question 15

What is metainflammation?

Answer 15

Chronic low grade inflammation response to obesity.