ADHD and Medications Flashcards

1
Q

How long do ADHD symptoms need to be present for prior to diagnosis?

A

at least 6 months

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2
Q

What are the three types of ADHD?

A
  1. Hyperactive/impulse
  2. Inattentive
  3. Combined
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3
Q

What assessment tool is available for parents/teachers to use to report ADHD symptoms?

What age range is this assessment tool useful for?

A

Vanderbilt Assessment Scale

for ages 6-12 yo

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4
Q

Using the Vanderbilt Assessment Scales, to meet criteria for ADHD what 2 criterion must be met between the symptoms and performance sections?

A
  1. 6+ (+) responses in hyperactive or inattentive symptoms in “Behaviors” section
  2. Must have 2 ‘4s’ or 1 ‘5’ in the “Performance” section
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5
Q

What are the two major categories of ADHD medications?

A

Stimulants and Non-Stimulants

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6
Q

What are the two classes of Stimulants used to treat ADHD?

A
  1. Methylphenidates
  2. Amphetamines
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7
Q

What are the 3 most common methylphenidate medications used to treat ADHD?

A
  1. Ritalin
  2. Concerta
  3. Focalin
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8
Q

What are the 2 most common amphetamine medications used to treat ADHD?

A
  1. Adderall
  2. Vyvanse
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9
Q

What are the 3 most common non-stimulant medications used to treat ADHD?

A
  1. Strattera (atomoxetine)
  2. Clonidine
  3. Guanfacines
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10
Q

What is the generic name for Strattera?

A

Atomoxitine

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11
Q

What is the generic name for Ritalin?

A

Methylphenidate hydrochloride

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12
Q

What is the generic name for Concerta?

A

Methylphenidate hydrochloride extended release

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13
Q

What is the generic name for Focalin?

A

Dexmethylphenidate

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14
Q

Are these stimulants long or short-acting?

Ritalin
Concerta
Focalin

A

Ritalin - SHORT acting
Concerta - LONG acting
Focalin - SHORT acting

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15
Q

What are the three major side effects of methylphenidate medications?

A
  1. decreased appetite
  2. sleep disturbances
  3. cardiac
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16
Q

Are these stimulants long or short-acting?

Adderall
Vyvanse

A

Adderall - SHORT acting
Adderall XR - LONG acting
Vyvanse - LONGEST 1/2 life

17
Q

Which amphetamine medication is the best for concomitant anxiety symptoms?

18
Q

What side effect is commonly seen with amphetamine use?

A

emotional reactivity

19
Q

What are two main side effects of non-stimulant ADHD medications?

A

drowsiness (3-5 days) and dizziness

  • alpha 2 agonists
20
Q

Ritalin (IR) dosing

Children 3-5 yo
Children 6 yo+

A

3-5: initial 2.5 mg BID, gradually titrate to 7.5 mg BID/TID over 2-4 wks

6+: initial 2.5-5 mg BID, inc. by 5-10 mg/day at weekly intervals
- Max: 2 mg/kg/day

21
Q

Concerta (XR)

Children 6+ who are methylphenidate-naive
Children 6+ who are switching from IR to XR (4)

A

Naive: 18mg QD

Not naive:

  1. 5 mg IR BID/TID –> 18 mg QD
  2. 10 mg IR BID/TID –> 36 mg QD
  3. 15 mg IR BID/TID –> 54 mg QD
  4. 20 mg IR BID/TID –> 72 mg QD
22
Q

Concerta (XR)

How do dose adjustments occur?

What is the max daily dosing? (age 6-12 vs 12+)

A

Adjust: inc. by 18 mg/day at weekly intervals

Max dosing:
- 6-12: 54 mg/day
- 12+: 72 mg/day

23
Q

Focalin (6yo+)

Methlyphenidate naive dosing (IR and XR) vs switching from methylphenidate

A

Naive:
- IR: 2.5 mg BID, inc. 2.5-5mg/day weekly (Max: 20mg/day)
- XR: 5 mg QD, inc. 5mg/day weekly (Max: 30mg/kg/day)

Switching:
- initial dose: 1/2 methylphenidate dose

24
Q

Adderall (IR)

3-5 yo dosing vs 6+ yo dosing

A

3-5: 2.5 mg QD, inc. 2.5mg/day weekly (Max: 40mg/day in 1-2 divided doses)

6+: 5 mg QD/BID, inc. 5 mg/day weekly (Max: 40mg/day)

25
Adderall (XR) 6-12 yo vs 13-17yo dosing What is the dosing if switching from IR Adderall to XR Adderall?
6-12yo: 5-10mg QD, inc. 5-10mg/day weekly (Max: 30mg/day) 13-17yo: 10mg QD, inc. to 20mg QD after 1 week if not controlled (Max: 20mg/day) **if switching from IR to XR:** use same total daily dose of IR taken QD as XR form
26
Vyvanse (6yo+) Initial dosing
Initial: 20-30mg QD morning Increase 10mg/day or 20mg/day at 3-7 day intervals Max: 70mg/day
27
Strattera (6yo+) <70 kg vs >70 kg dosing
<70kg: 0.5mg/kg/day, inc. to 1.2mg/kg/day after 3 days - given QD or BID - Max: 1.4 mg/kg/day or 100mg/day >70kg: 40mg QD, inc. to 80mg after 3 days - given QD or BID - Max: 100mg/day
28
Clonidine (IR, 6+ yo) 27-40kg dosing 40.5-45kg dosing >45kg dosing
27-40: 0.05mg at bed, inc. 0.05mg/day every 2-3 days given BID/TID - Max: 0.2mg/day 40.5-45: 0.05mg at bed, inc. 0.05mg/day every 2-3 days given BID/TID/QID - Max: 0.3mg/day >45kg: 0.1mg at bed, inc. 0.1mg/day every 2-3 days - Max: 0.4 mg/day
29
Clonidine (XR, 6+ yo) Dosing, increasing dose, max dose **How long is clonidine tapered over?**
Initial: 0.1mg/day at bedtime - inc. 0.1mg/day every 7 days BID - Max: 0.4mg/day Tape over **1-2 weeks**
30
Guanfacine (IR, 6+ yo) <45kg dosing vs >45kg dosing
<45kg: 0.5mg QD at bed, inc. 0.5mg/day BID/TID/QID every 3-4 days - Max: 0.2mg/day (27-40.5kg) or 0.3mg/day (40.5-45kg) >45kg: 1mg QD at bed, inc. 1mg/day BID/TID/QID every 3-4 days - Max: 4mg/day
31
What is the best initial treatment option for preschool aged children (4-5 yo) who present with ADHD symptoms?
Behavioral Management +/- methylphenidates if behaviors not well controlled methylphenidate >>> amphetamines or non-stimulants
32
How often should patients on ADHD medications be seen in follow-up? (Initial vs maintenance)
Initial: every 1-2 weeks or per titration standards Maintenance: every 3-6 months depending on other issues
33
At therapeutic dosing, how quickly should the effects of stimulant medications be noticed?
within **30-40 minutes** of administration