Adenovirus Flashcards
Infect mamals
Mastadenovirus
Infect birds
Aviadenovirus
Atleast how many proteins
11
•Relatively stable, remaining viable for about a week at
37 degree Celsius
Are readily inactivated at
50 degree Celsius
Resist using
Ether and bile salt
Disease Mechanisms of Adenoviruses:
Virus is spread by aerosol, close contact, or fecal-oral means to establish__________________. Fingers spread virus to eyes.
pharyngeal infection
Disease Mechanisms of Adenoviruses:
Virus infects mucoepitheal cells in the ______________ tract, _____________ tract, and __________ or _________, causing cell damage directly.
respiratory tract, gastrointestinal tract, and conjunctiva or cornea
Disease Mechanisms of Adenoviruses:
Virus persists in __________ tissue
lymphoid tissue
Disease Mechanisms of Adenoviruses:
is important for prophylaxis and resolution but cell-mediated immunity is also important.
Antibody
Epidemiology of Adenoviruses: Disease/Viral Factors
Capsid virus is resistant to inactivation by gastrointestinal tract and drying
Disease symptoms may resemble those of other respiratory virus infections
Virus may cause asymptomatic shedding
Epidemiology of Adenoviruses: Transmission
Direct contact via respiratory droplets and fecal matter, on hands, on fomites
Epidemiology of Adenoviruses: Who Is at Risk?
Children younger than 14 years of age
People in crowded areas
Epidemiology of Adenoviruses: Geography/Season
Virus is found worldwide
There is no seasonal incidence
Epidemiology of Adenoviruses: Modes of Control
Live vaccine for serotypes 4 and 7 is available for military use
the major cause of nonbacterial pharyngitis and tonsillitis, presenting as febrile common cold.
Pharyngitis
Serotype pharyngitis
Type 1-7
are associated with pneumonia in adults resembling primary atypical pneumonia
Pneumonia
Serotype pneumonia
Serotype 3 and 7
Infant serotype in pneumonia
Serotype 7
disease
(ARD) syndrome among military receuit
Acute respiratory disease
Serotype acute respiratory disease that commonly isolated
Serotype 4, 7, and. 21
tends to occur in outbreaks, such as at children’s summer camps
Pharyngoconjunctival fever
Pharyngoconjunctival feverAlso know as
Swimming pool conjunctival
a serious condition which may appear as an epidemics,
Epidemic keratoconjunctivitis (EKC)
Serotype epidemic keratoconjunctivitis usually caused by
Serotype 8
Serotype epidemic keratoconjunctivitis less often type
Serotype 19 and 37
Serotype acute follicular conjunctivitis
Serotype 3,4 and 11
Some fastidious adenoviruses can cause diarrheal disease in children
Diarrhea
Serotype diarrhea
Serotype 40 and 41
Are members of the parvoviridae.
Adenovarus associated viruses
Adenovarus associated virus (AAV) •Form a genus,
Dependovirus
True AAV Also known as
adenovirus satellite virus
Not been implicated in clinical disease and its pathogenic role is uncertain.
True AAV