ADE Flashcards
1
Q
Cholinesterase inhibitor poisoning
A
Often due to organophosphates, such as
parathion, that *irreversibly inhibit AChE
Organophosphates are often components of *insecticides; poisoning usually seen in farmers.
DUMBBELSS
Diarrhea Urination Miosis Bronchospasm Bradycardia Excitation of skeletal muscle and CNS Lacrimation Sweating Salivation
May lead to *respiratory failure if untreated.
Antidote—atropine (competitive inhibitor) +
pralidoxime (regenerates AChE if given early).
