Additional Antibiotic Questions Flashcards
Are beta lactams water soluble or lipid soluble?
Water soluble
Are Aminoglycosides water soluble or lipid soluble
water soluble
Are fluoroquinolones water soluble or lipid soluble?
Lipid soluble
Is doxycycline water soluble or lipid soluble?
Lipid soluble
Are aminoglycosides affective against anaerobes? What is their spectrum? What specific organism are they not good at ?
Yes because they require a high oxygen environment, so anaerobes are resistant to aminoglycosides.
Mostly g-
Not good at enterococcus (gram +)
What antibiotic in combination with hypocalcemia causes ototoxicity?
Aminoglycosides
What antibiotic targets organisms without cell walls and mycobacterium?
Fluoroquinolones
What is the spectrum of fluoroquinolones?
Gram -
Less g+
What is the reason for fluoroquinolone resistance?
Changes in the target topoisomerase
What is the least likely fluoroquinolone to cause retinal degeneration in cats?
Marbofloxacin
What antibiotic causes cartilage damage in young animals?
Fluoroquinolones
Name two antibiotics good at treating mycobacterium
Rifampin
Enrofloxacin
What is the spectrum of Rifampin
Gram +
Mycobacterium
What are side effects of TMS drugs?
Hypersensitivity, KCS, T4 suppression
Which antibiotic is 99% protein bound?
Doxycycline
What antibiotic causes discoloration of teeth in young animals?
Tetracyclines
What are antibiotics effective against pseudomonas?
3rd generation cephalosporins
aminoglycosides
carbapenam
enrofloxacin
Do aminoglycosides release a lot of endotoxin when killing bacteria?
No
Do beta lactams release a lot of endotoxin when killing bacteria? Which one releases the least?
Yes because they lyse cell walls and release high amounts of endotoxin
(iminpenem releases the least amount of endotoxin)
T/F: Beta lactams work synergistically with aminoglycosides?
True
Is gentamicin or amikacin better at staphylococcus?
Gentamycin
Is gentamicin or amikacin better at pseudomonas?
Amikacin
Name 4 antagonistic antibiotic concentrations
Beta-lactams and Beta lactams (BB)
Beta-lactams and Chloramphenicol (BC)
Fluoroquinolones and tetracyclines (FT)
Erythromycin and aminoglycosides (EA)
