Addison And cushing Flashcards

1
Q

Inadequate corticosteroid and mineralocorticoid synthesis
Which disease

A

Addison disease

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2
Q

Elevated ACTH levels
What disorder

A

Addison

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3
Q

Symptoms of Addison disease are a result of what two conditions

A

Hypocortisolism
Hypoaldosteronism

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4
Q

Hypocortisolism
Hypoaldosteronism
What condition

A

Addison

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5
Q

Hypocortisolism
What condition

A

Addison

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6
Q

Hypoaldosteronism
What condition

A

Addison

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7
Q

Aldosterone’s primary function is to act on what organ

A

Kidney

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8
Q

What hormone?
Favors sodium and water reabsorption and potassium excretion

A

Aldosterone

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9
Q

What two things does aldosterone favor resorption?

A

Sodium
Water

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10
Q

Aldosterone favors excretion of what

A

Potassium

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11
Q

Hyperkalemia in Addison is a result of what

A

Not enough aldosterone

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12
Q

Why is there hyperkalemia in Addison disease?

A

Not enough aldosterone

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13
Q

Hypovolemia in Addison disease why?

A

Not enough aldosterone

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14
Q

All clinical manifestations related to excessive exposure to cortisol

A

Cushing syndrome

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15
Q

Hypokalemia
Cushing or Addison

A

Cushing

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16
Q

Hyperkalemia
Cushing or Addison

A

Addison

17
Q

Hyperglycemia or hypoglycemia in Cushing

A

Hyperglycemia

18
Q

Sodium imbalance in Cushing?
Think opposite of Addison

A

Hypernatremia

19
Q

Potsssium imbalance in Addison?

A

Hyperkalemia

20
Q

Potassium imbalance in Cushing?

A

Hypokalemia

21
Q

Three signs (physical) of Cushing

A

Truncal obesity
Moon face
Buffalo hump

22
Q

Cortisol induced insulin resistance leads to what type of intolerance

A

Glucose

23
Q

Why is there hyperglycemia in Cushing syndrome?

A

Increased gluconeogenesis and glycogen storage by the liver

24
Q

Increased gluconeogenesis and glycogen storage by the liver lead to what in Cushing?

A

Hyperglycemia

25
Q

Catabolic effects of cortisol on peripheral tissues is caused by what in Cushing

A

Protein wasting

26
Q

Where is muscle wasting in Cushing most prominent?

A

Muscles of extremities
Thinning of limbs

27
Q

Thin weakened integumentary tissues are due to loss of what

A

Collagen

28
Q

Exogenous Cushing like syndrome due to what

A

Long term administration of glucocorticoids

29
Q

Purple striae and easy bruising
What condition

A

Cushing

30
Q

Loss of what leads to purple striae and easy bruising?

A

Collagen