Addiction - Unit 4 Flashcards
Corrigall and Coen 1977
DOPAMINE REWARD SYSTEM
When rat pressed a lever, nicotine was delivered directly into the rats reward pathway. The rats quickly learnt to press the lever to get a nicotine release, suggesting that nicotine is rewarding, and therefore addictive due to its affect on the reward pathway of the brain.
Corrigall and Coen - dopamine blocked
When dopamine release was blocked, then self administration of nicotine reduced, suggesting that the effect nicotine has on dopamine is addictive.
Thorgeirsson
GENETIC VULNERABILITY
Found a cluster of genes on chromosome 15 associated with a type of nicotine receptor in the brain. This gene cluster was also linked to a greater number of cigarettes being smoked a day and to nicotine dependency. Some people may be more vulnerable
Schuck
People who had close relatives who were alcoholics reported feeling less intoxicated after an alcoholic drink than a matched group whose relatives did not abuse alcohol. This suggests the high risk group may have inherited a difficulty in recognising when they have drunk too much, making them at a greater risk for alcohol a nude problems.
Coming 1986
Found that pathological gamblers are more likely to have a version of the DRD2 gene. This gene reduces the number of dopamine receptors in the reward pathway, so gambling and other impulsive behaviours that boost dopamine will be more rewarding.
Conner et al
SUPPORTS COGNITIVE AND TPB MODEL
Questioned 675 11-12 yo who had not smoked about their intentions to smoke. Nine months later, intention to smoke was a good predictor of who had taken up smoking (self report and carbon monoxide on breath).
Griffiths 1994
Regular gamblers were more likely to show irrational thoughts about gambling, such as personifying the machine and explaining away losses
NIDA
Found 90% of American smokers reported starting to smoke as teenagers as a result of imitating peers
White and Hiroi 1993
CLASSICAL CONDITIONING
Rats preferred areas of the cage where they got amphetamines over areas of the cage where they did not get amphetamines - demonstrates learned associations
Childs 2010
STRESS AS VULNERABILITY FACTOR
Smokers craved cigarettes significantly more after a social stress test than after a non stressful task
Cleck and Blendy
Supported this in their review which found a correlation between abuse in childhood and addictive behaviour in adulthood
Garnier and Stein
PEERS AS VULNERABILITY FACTOR
Longitudinal study of 198 families over 18 years, substance abuse in peers was associated with substance abuse in teenagers
Bricker
Longitudinal study of 6,000 adolescents found that close friends influenced initiation and maintenance of smoking. Therefore, we should not overlook the role of parental behaviour by focusing too much on the role of peers.
Shram
AGE AS VULNERABILITY FACTOR
Found adolescent rats were more sensitive to the rewarding effects of nicotine than adult rat. This suggests biological factors in the teenage brain may make it more vulnerable to addictions (so teenage addiction is not just about peer pressure)
Hefler
Found 46% of over 75 year old men drink each day compared to only 6% of 25-34 year olds