addiction Flashcards
physical dependence
develops after using for a long time
when abstanance occurs the withdrawal symptoms are physical
pyschological dependence
when someone thinks they need a substance
when abstnance occurs withdrawal symptoms are mental
tolerance
develops from continous using
body has adjusted so homeostatis is changed and bar is raised so more substance is needed to have same effect
2 types of tolerance
behavioural - adjust behaviour to deal with effects of a substance
cross - tolerance to one drug reduces sensitivity to another
5 risk factors increasing addiction
genetics , peers , family, stress, personality
how genetics increase addiction
few D2 receptors - less dopamine - uses to compensate
fully functioning CYP2A6 Enzyme - nicotine digests quicker so is injested more frequently
Genetic vulnreability study - Kendler et al
studied adopted children some with addict parent , some without to see if they developed addiction
with - 8.6%
without- 4.2%
how stress increases addiction
may use substances as a coping mechanism
2in 10 people with PTSD have an addiction
2 types of stress
chronich - ongoing
accute - stress due to an event
how personality increases addiction- 3 traits
sensation seeking - want excitement
impulsivity - don’t think of consequences
compulsivity - don’t stop when they know they should
A03 Of personality causing addiction
addiction may have caused these traits
not having these traits is protection
how family with addiction increases addiction
SLT as parents are role models
increases availability of substances
normalises the behaviour
Livingston et al - family influence
children who are allowed to drink at home go on to drink excessivley in college
how peers increase addiction
as a child , peers have greatest influence
SLT
increases availability
mesembolic pathway of nicotine
inhaled through mouth
reaches VTA in 6-10s - binds with receptors to carry message to nucleas acumbens
at NA dopamine is released - euphoric feeling
PFC makes decision on what to do next
memory of pleasure laid in hippocampus
amount of dopamine released from nicotine
2-10x natural pleasure
other than dopamine , nicotine effects 3 things
release of glutamate - triggers more dopamine
prevents GABA- amplifies effect of dopamine
stops MAO - nicotine not broken down
explanation for nicotine addiction - withdrawal receptors
nicotine binds with acetycholine receptors on dopamine neurons making them full
they desensitize
after abstinance they function again so crave nicotine making withdrawal kick in
explanation for nicotine addiction - chronic desnentitsation
contsant cycles of desntisisation and resensitization leads to chronic densentization which means they become tolerant to nicotine
Research - Olds and Miller - dopamine
rats had an electrode connected to hypothalamus which is stimulated when dopamine released
a pedal stimulated hipothalamus so rats would press it even when they had to walk over an electric shock
Individual differences in reward pathway -Schiffman
Chippers - can smoke 5x a day and not show withdrawal during abstanace
application of reward pathway - Lindsay
found that nicotine replacement therapy was 70% more accurate than other treatments due to reward pathway
implications of reward pathway
undertsanding it reduces strain on NHS - £5 million a year on smokers
Pros and Cons of reward pathway explanation
pros - scientific, simplifies behaviour
cons - reductionist , doesn’t explain cause
Initiation of nicotine - SLT
vicarious reinforcement - see role models receive positive reward from smoking so copy
maintenance of smoking - OC
positive reinforcement - mesolimbic pathway / fitting in with peers
negative reinforcement - avoid withdrawal / avoid being odd one out
Relapse of smoking - CC
cue reactivity
cue ( lighter) becomes CS as has repeatedly paired with idea of smoking.
Makes cravings stronger as anticipation of smoking, when our body anticpates dopamine it lowers levels
examples of cues
places , people , situations, objects