Adaptive immunity Flashcards
What does adaptive immunity refer to?
the body’s ability to defend
itself against specific invading agents
Antigens are substances recognized
recognized as foreign that provoke immune responses
Adaptive immunity has both specificity and memory and is divided into 2 types
- Cell-mediated
- Antibody-mediated
Immunogenicity -
the ability of cells/tissues to provoke an immune responses
- Reactivity
Entire microbes or just parts of microbes may act as
antigens
Epitopes.
certain small parts of a large antigen molecule act as the triggers for immune responses.
B cells function
can recognize and bind to antigens in lymph,
interstitial fluid, or blood plasma (controlling
extracellular pathogens)
only recognize fragments of antigenic proteins
that are processed and presented in a certain way
(controls intracellular pathogens)
T cells function
What are cytokines?
small protein hormones that stimulate or
inhibit many normal cell functions
Interleukin-1
Produced by macrophages; promotes proliferation
of helper T cells; acts on hypothalamus to cause fever
Interleukin-2
costimulates proliferation of helper T cells, cytotoxic T cells, and B cells: activates NK cells
Interferons (IFNs)
(in′-ter-FE-R-ons)
Produced by virus-infected cells to inhibit viral
replication in uninfected cells;
Interferons activate
activate cytotoxic T cells and natural killer cells, inhibit cell division, and suppress the formation of tumors.
Macrophage migration inhibiting factor
Produced by cytotoxic T cells; prevents
macrophages from leaving site of infection.