Adaptive Immune Response

Question 1

What are the three things that Antigen Presenting Cells must tell T cells?

Answer 1

“There is an invader inside the cell”
“This is what it looks like”
“This is what you need to do”

Question 2

Antigen presenting cells need to communicate to T cells to tell them what 3 things?

Answer 2

“There is an invader inside the cell”
“This is what it looks like…”
“This is what you need to do….”

Question 3

What are the main features of APCs?

Answer 3

Placed in strategic locations
Able to capture pathogens
PRR diversity

Question 4

In what locations can APCs be found?

Answer 4

Skin (SALT)
Mucous membranes (MALT)
Lymphoid organs (Lymph nodes, spleen)
Blood circulation (Plasmacytoid, myeloid DCs)

Question 5

What are the main professional APCs?

Answer 5

Dendritic cells
Macrophages
B cells

Question 6

Which cells are the only cells that are able to present bacterial peptides? 
What MHC class are responsible for presenting bacterial peptides?

Answer 6

Dendritic cells

MHC II

Question 7

Viruses always elicit a response from which T helper cells?

Which then activates the response of which T cells?

Answer 7

TH 1

CD8 + T cells –> Cytotoxic T cells

Question 8

Which response generated by the immune system blocks the action of bacterial toxin?

Answer 8

Antibody response by binding to toxins and neutralising them

Question 9

Which MHC class is expressed on all nucleated cells?

Answer 9

MHC I

Question 10

In order to elicit a response to intracellular microbes, we need which MHC class?

Answer 10

Both MHC I and MHC II