Adaptive Immune Diseases Flashcards
What contibutes to Autoimmune DIsease?
Mess up in Negative selction w/ B and T Cells
What are the 4 types of ADs that are T-cell mediated? (Type IV)
- Diabetes type 1
- Rheumatold arthritis
- Multiple sclerosis
- Celiac Disease
What are the 3 Immune-complex disease (type III)?
Endocarditis
Cryoglobulinemia
Erythematosus (lupus)
What SEX gets more ADs?
Females
How many of those that have the predisposed gene actually get autoimmune disease?
20%
What 3 things cause ADs?
Genetics
Environment
Both (trauma can too)
What Gene is associated w/ ADs 50% of the time?
HLA
What cells are closly tied w/ AD development?
CD4 T-Cells
Class II
Rheumatic Fever is casued by…
Molecular Mimicry
Strep Pyogenes cause… why?
Rheumatic Fever and they share human epitopes
Graves’ Disease is caused by what cell response?
CD4 Th2
In Graves’ Disease Antibodies function as…
a TSH agonist
Can Graves’ Disease be given to babies?
Yup they sure can dude
What cells respond to Hashimoto’s Disease?
CD4 TH1
What is Hashimoto’s Dsease?
Hypothyroidism
Hyperthyroidism is
Graves’ Disease
Hypothyroidism is
Hashimoto’s Disease
What type of Hypersensitivity is Sjorgen’s Syndrome?
Type II
Some Symptoms of Sjogren’s Syndrome
Dry everything
Things that happen w/ dry mouth
What comes w. Lupus?
Kidney Dysfunction and a face wolf mask thing
How is Periodontitis related to Rheumatoid Arthritis?
By epitope spreading w/ citrullinated proteins
Type IV Hypersensitivity is mediated by
CD4 and CD8
What is the Epitope Spreading w. Type I Diabetes?
Intraepitope
Interepitope
