Acute Respiratory Distress Syndrome Flashcards
What is ARDS ⁉️
It’s a hypoxemic respiratory failure due to systemic or pulmonary inflammation without evidence of heart failure or pulmonary hypertension
When the acute lung 🫁 injury turns into ARDS ⁉️
When it’s very severe
What happened to the pulmonary capillary wedge pressure in ARDS ⁉️
🔸It’s stayed normal
🔸less than 18
What is the mechanism of ARDS
🔸systemic or pulmonary inflammation
🔸increases the capillary permeability
🔸accumulation of fluid between the alveoli and the blood vessel
🔸that will decrease the O2 diffusion
🔸increase the pressure outside the alveoli and causes lung 🫁 collapse
What is the difference between ALI and ARDS ⁉️
🔹PO2:Fio2 less than 200
🔹PO2:Fio2 less than 300
Risk factors for ARDS ⁉️
🔹direct lung injury
🔹systemic inflammation
Direct lung injury that causes ARDS 🫁
🔆pneumonia
🔆fat embolism
🔆drowning
🔆inhalation injury
🔆aspiration of gastric contents
Systemic causes that lead to ARDS ⁉️
🔹sepsis
🔹shock
🔹pancreatitis
🔹drug overdose
🔹massive transfusion
The main two factors in the ARDS ⁉️🫁
🔹 ⬇️surfactant
🔹⬆️endothelial damage and capillary permeability
🔹⬆️alveolar collapse
What are the 3 phases of ARDS ⁉️
🔹exudative phase
🔹proliferation phase
🔹fibrotic phase
What happened in the exudative phase of ARDS ⁉️
🔹it takes 7 days
🔹damage of type 1 alveolar cell
🔹damage of vascular endothelium
🔹leakage of water,proteins,inflammatory cells into the intrerstium between alveoli and capillary
🔸producing of hyaline membrane
🔸each lung weight 1000 instead of 200
What happened to the proliferation phase in ARDS ⁉️
🔸1-3 weeks
🔸damage to type 2 alveolar cell➡️that will decrease the surfactant
🔸parietal fibrosis and remolding
What happened in the fibrotic phase of ARDS ⁉️
🔹more than 3 weeks
🔹end stage fibrosis
🔹collagen deposits
How we could differentiate between ARDS and respiratory failure due to cardiac conditions or pulmonary hypertension
By using Berlin score
Berlin definition of ARDS ⁉️
🔆1 week of respiratory symptoms onset or acute worsening
🔆bilateral opacities on X-ray 🩻
🔆RF not explained by Cardiac failure 🫀or fluid over load
🔆imparted oxygenation