Acute Respiratory- Adults Flashcards

(79 cards)

1
Q

acute bronchitis

A
  • Acute bronchitis is a lower respiratory tract infection involving the large airways (bronchi), without evidence of pneumonia, that occurs in the absence of chronic obstructive pulmonary disease.
  • Self-limited inflammation of the bronchial respiratory mucosa leading to productive or non-productive cough
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2
Q

acute bronchitis: s/s

A

o Cough persisting > 5 days
o Dry or Productive
o May last several weeks
o +/- wheezes, rhonchi (will clear with cough)
o Fever/systemic symptoms typically absent
o Chest wall tenderness from coughing is common
o Often preceded by URI symptoms

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3
Q

acute bronchitis: diagnostics

A

o Based on hx and PE
o Focus should be on ruling out more serious illness
o CXR indicated only when clinical features suggest pneumonia

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4
Q

acute bronchitis: differentials

A

o Pneumonia, COVID, Influenza, etc.
o Postnasal drip/upper airway cough syndrome
o GERD
o Asthma
o COPD
o ACEI use
o Heart Failure
o PE
o Lung Cancer

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5
Q

tx for symptomatic acute bronchitis

A

o Cough suppressants:
* Dextromethorphan
* Guaifenesin
* Honey
* Codeine
o Humidification
oAntihistamine/Decongestants/Analgesics – if associated URI symptoms or muscle pain from cough
o Inhaled beta-agonists: Albuterol
* If wheezing or underlying lung disease
o Antibiotics are generally NOT indicated

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6
Q

acute bronchitis: pt education

A

o A nagging cough can last for several weeks
o Antibiotics are not indicated for acute bronchitis
o **You should follow-up in the office if you develop:
* A fever higher than 100.4°F (38°C)
* Chest pain when you cough, trouble breathing, or coughing up blood
* New discolored mucus (getting progressively darker)
* A barking cough that makes it hard to talk
* A cough and weight loss that you cannot explain

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7
Q
  • Pneumonia is unlikely if all of the following are absent:
A
  • fever >/ 100.4
  • tachypnea >/ 24
  • tachycardia >/100
  • evidence of consolidation on chest exam: rales, egophony, fremitus
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8
Q

pertussis “whooping cough”

A

highly contagious

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9
Q

pertussis presentation

A

o Stage 1: Catarrhal period 1-2 weeks
* Nonspecific malaise, rhinorrhea and mild cough
* Excessive lacrimation and conjunctival injection are usually present
o Stage 2: Paroxysmal coughing fits that can last 2-3 months
* Characteristic “whoop” or barking cough
* Post-tussive syncope or emesis often present
* Otherwise feel well
o Stage 3: Convalescent; less persistent cough lasts 1-2 weeks

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10
Q

pertussis clinical criteria for testing

A

o Cough lasting >/= 2 weeks, without a more likely diagnosis and at least 1 of the following:
* Paroxysms of coughing
* Inspiratory whoop
* Posttussive vomiting

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11
Q

diagnosis pertussis

A

choice of testing depends on duration of cough
* culture (nasal swab or aspiration): gold standard
* PCR (nasal swab or aspiration)
* serology

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12
Q

tx of pertussis

A

o 1st line: Macrolide antibiotics (azithro or clarithromycin)
o 2nd line: Bactrim
o Close contacts should also be treated regardless of immunization history
o Abx treatment does not necessarily improve cough symptoms but reduces transmission to others

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13
Q

complications of pertussis

A

o Super-Infection (Pneumonia)
o Mechanical r/t severe cough (abd hernia, subconjunctival hemorrhage, rib fractures)
o Morbidity and mortality most common in infants and young children
o Adults can experience significant time away from work/school, social isolation, sleep deprivation, anxiety

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14
Q

pertussis prevention–vaccination

A
  • Tdap: tetanus booster + reduced dose of diphtheria and pertussis approved for age 11-64
    1 dose between 11 and 18
    1 booster dose between 19 and 64
  • Adults > 64 who have not previously received Tdap should receive a single booster
  • Pregnant women should receive a Tdap booster btwn 27 and 36 weeks during every pregnancy
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15
Q

pneumonia

A
  • Infection of the lower respiratory tract classified by how it is acquired
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16
Q

pneumonia etiology

A

o Typical bacteria: Streptococcus pneumoniae (60-70%) (although incidence is decreasing), Haemophilus influenzae, and Moraxella catarrhalis
o Atypical bacteria: Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae
o Viruses: Influenza, rhinovirus, adenovirus, COVID-19

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17
Q

pneumonia risk factors

A

o Older age (>65)
o Smoking
o Alcohol use >80 gm/d (> 5 drinks)
o Comorbidities (COPD/lung disease, CHF, DM, malnutrition, stroke, immunocompromise)
o Viral respiratory infection
o Crowded living conditions

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18
Q

presentation pneumonia

A

loof for fever, chills, rigors, cough, malaise

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19
Q

presentation pneumonia typical

A
  • age <5 or >40
  • onset: abrupt
  • cough: productive
  • sputum: rusty/purulent
  • rigors: often present
  • fevers > 39 C
    consolidation: present
    leukocytosis: 15+, shift
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20
Q

presentation pneumonia: atypical

A
  • age: <40
  • onset: gradual
  • cough: paroxysmal, non-productive
  • sputum: minimal, mucoid
  • rigors: absent
  • fevers <39 C
  • consolidation: often absent
  • leukocytosis: often absent
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21
Q

pneumonia diagnosis

A

o Physical Exam:
* Full HEENT, respiratory exam, cardiac exam
* Significant findings: rales (unilateral= bacterial; bilateral= atypical) that do not clear with cough, bronchial breath sounds, dullness to percussion, egophony (E to A changes)
* Imaging:
* CXR (A/P plus lateral): can be normal in early disease, may show infiltrative changes

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22
Q

pt teaching pneumonia

A

o Clear directions for antibiotic use
o Follow up in 24 to 48 hours by phone or in person
o Push fluids by mouth
o Use antipyretics prn fever & myalgias
o If constant non-productive cough, try codeine, esp. qhs

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23
Q

tx pneumonias

A

o IDSA guidelines: monotherapy with Amoxicillin, Doxycycline, or Macrolide if there are risk factors for MRSA, pseudomonas, or comorbidities
o Duration of Treatment
* Outpatient: generally 5 days

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24
Q

follow-up pneumonia

A

o Clinical follow-up 24-48 hours after initiation of treatment is appropriate
* Assess VS, mentation, appetite

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25
referral to hospitalization: pneumonia
o CURB-65 Calculator-- Confusion, Uremia >7, RR >/ 30, BP <90/<60, Age>/65 o Pneumonia Severity Index (PSI) Calculator
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pneumonia prevention
o Smoking cessation o Influenza vaccination o Pneumococcal vaccination for at risk patients o Ongoing infection control measures
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pneumonia vaccination
PCV20 - Pneumococcal polysaccharide vaccine * average risk adults >/ 65- one dose PPSV23 * recommended for adults >/ 65 and persons 19-64 with DM, ETOH, liver disease, cigarette smoker, chronic heart disease PCV7/13/15/20 * childhood series, adults >/65, adults with immunocompromise, asplenia, CSF leak, cochlear implant, advanced kidney disease
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infiltrative changes: typical pneumonia
unilateral: only one side of the lobe is inflamed and will be seen on imaging
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infiltrative changes: atypical pneumonia
bilateral-- both lower lobes are severely inflammed and will see on imaging
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COVID-19: s/s
o Cough o Fever o Myalgias o Headache o Dyspnea o Sore throat o Diarrhea o N/V o Chest pain o Anosmia or other smell abnormalities o Agnosia or other taste abnormalities o Rhinorrhea and/or nasal congestion o Confusion
31
testing for COVID-19
o Symptoms= test immediately o Exposed to COVID-19 w/o sx, wait at least 5 full days before testing. Too early = false negative o If you are in certain high-risk settings*, routine testing programs. o Consider testing before contact with someone at high-risk for severe COVID-19, especially if you are in an area with a medium or high COVID-19 Community Level. o **High-risk settings: congregate living, prisons, LTC, hospitals
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diagnosis: COVID-19
gold standard: PCR, NAAT
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risk for severe COVID-19
* age >/ 65 years * asthma * cancer * heart conditions * smoking * diabetes * chronic lung disease * physical inactivity * pregnancy or recent pregnancy * substance use disorders
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who to treat: COVID-19
acute illness and at least 1 of the following: * > 64 yrs old * immunosuppression * risk factors for severe COVID-19 * >49 years old and unvaccinated
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what to treat with: COVID-19
* Nirmatrelvir-ritonavir (Paxlovid) * Molnupiravir * Remdesivir
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Nirmatrelvir-ritonavir (paxlovid)
* Protease inhibitor (not unlike those used for HIV treatment) * Must be started by 5th day from start of symptoms * Generally, very well tolerated
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Nirmatrelvir-ritonavir (Paxlovid): contraindications/precautions
o Contraindicated: * Anti-arrhythmics (flecainide, amiodarone) * Anti-psychotics (clozapine, lurasidone) * Anti-seizure (phenytoin, phenobarbital, carbamazepine) o Hold or adjust: * Statins (esp. lova- simva-)
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Nirmatrelvir-ritonavir (Paxlovid): side effect
covid rebound o Mild sx returning after completion of antiviral course (24-48hrs) o Rare progression to severe symptoms o If sx recur, recommend antigen retesting and extend isolation if positive.
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pt teaching: COVID-19
* Clear directions for antiviral use * Follow up in 24 to 48 hours * Push fluids by mouth * Use antipyretic to control fever & myalgias as needed * OTC cough suppressants, codeine may be appropriate * Isolation: o Isolate 5 day from start of symptoms o Continue to wear mask for additional 5 days. o If “rebound” and antigen is positive, isolate for additional 2 days, then retest o Repeat testing not generally recommended
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long COVID s/s
* fatigue * dyspnea * chest discomfort * cough * anosmia (loss of smell)
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covid-19 prevention
* 6 ft distance * Wear masks * Do not touch mouth, eyes, nose, * Stay at home if you are sick * Clean and disinfect surfaces * Hand hygiene
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COVID-19 vaccination
Who: o Everyone older than 6 months o Adults and children same frequency, different dosing * Immunocompromised – different recommendations Moving toward annual boosters o Flu-COVID combos
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upper respiratory infection ("common cold")
A self-limited viral illness of the upper respiratory structures
44
URI: common pathogens
o Rhinovirus (most common) o Coronavirus o Parainfluenza, adenovirus, enterovirus, RSV (more common in kids), & influenza
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URI: modes of transmission
o Hand contact o Direct contact with an infected person or indirect contact with a contaminated environmental surface o Small particle droplets: Airborne from sneezing or coughing o Large particle droplets: Requires close contact with an infected person o Cold-inducing viruses are viable on human skin and fomites for 2+ hours
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URI: infectivitiy
o Peak viral shedding is on the second and third day of illness o Low levels of viral shedding may persist for up to two weeks o 24-72 hour incubation period o Typical duration of illness is 3-10 days but can last up to two weeks o Smokers are more likely to experience prolonged symptom duration
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URI: risk factors
o Exposure to children in daycare, psychological stress, poor sleep
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URI: risk for increased severity
o Smoking, chronic illness, immunodeficiency, malnutrition
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s/s of URI
o Rhinitis o Nasal congestion: Clear and/or purulent discharge o Sore throat: Often described as “scratchy” or “dry” o Cough: Often begins a day or 2 after nasal symptoms o Malaise o Fever uncommon in adults but may occur in children o Don't judge your mucus by its color!
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diagnosis of URI
o PE is typically largely unremarkable o No diagnostic tests are routinely indicated
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physical exam findings: URI
o Eyes: possible conjunctival injection o Nasal mucosal swelling; nasal congestion o Pharyngeal erythema o Adenopathy: usually absent, or minimal o Lung exam: Usually clear unless secondary bronchospasm; e.g. wheezing
52
tx of URI
o Treatment is supportive/symptomatic! o Remember: Typically, self-limiting Rhinorrhea: * Intranasal cromolyn sodium (OTC NasalCrom) or ipratropium * Combination decongestants (pseudoephederine) and antihistamines (loratadine, fexofenadine, cetirizine, diphenhydramine) o Combination treatment thought to be more effective than either agent alone; antihistamines not helpful alon * Fever/Sore Throat/Headache/Malaise: o Analgesics/Antipyretics: acetaminophen, ibuprofen * Cough: o Antitussives (dextromethorphan) and expectorants (guaifenesin) shown to have marginal benefit at best; for mild symptoms, would not use
53
pt education on URI
o Review expected course and duration o Discuss symptomatic treatment and prevention of transmission (hand hygiene) o Provide reassurance that antibiotics are not needed and may have side effects o Follow-up in the office if they develop: * Persistent fever >100.5 * Shortness of breath * Persistent dark colored secretions
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Acute Rhinosinusitis (ARS)
* Symptomatic inflammation of the nasal cavity and paranasal sinuses lasting less than four weeks
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common pathogens of acute rhinosinusitis
o Most common pathogens: rhinovirus, influenza, parainfluenza
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Tx for acute rhinosinusitis
* Patients with acute viral rhinosinusitis (AVRS) should be managed with supportive care. There are no treatments to shorten the clinical course of the disease.
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s/s acute rhinosinusitis
o Nasal congestion/post-nasal drip o Halitosis (bad breath) o Headache o Referred dental pain o Fever o Ear fullness/otalgia o Hyposmia/anosmia (decreased sense of smell or no sense of smell at all) o May have sore throat, cough, nausea (often associated w/ post-nasal drip)
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physical exam: acute rhinosinusitis
o Assessment of vital signs, eyes, ears, pharynx, teeth, sinuses, lymph nodes, and chest o After vitals, start with eyes o Tenderness to palpation over the sinuses o Anterior rhinoscopy: mucosal edema & erythema, inferior turbinate hypertrophy, and rhinorrhea or purulent discharge o Post-nasal drip, cobblestoning (can see this in allergic conditions as well) o Good to also look at teeth, esp. if pt reports tooth pain. Use a tongue depressor to tap the teeth. o Role of Imaging: when indicated, CT without contrast
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diagnosis: acute rhinosinusitis
o Generally based on H&P o Do not rely on sinus palpation to assist w/ dx o For chronic symptoms or treatment failure consider: o CT scan w/o contrast (gold standard) o ENT referral o X-rays: low sensitivity/specificity o MRI: Not usually advised (tend to “overread”)
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tx of acute rhinosinusitis
first line: OTC analgesics and antipyretics, saline irrigation, intranasal glucocorticoids
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acute bacterial rhinosinusitis: s/s
* Persistent symptoms of ABRS lasting >10 days o Specifically fever, purulent discharge, facial/dental pain o Symptoms of a typical viral upper respiratory infection that are slowly improving but then worsen again with more severe symptoms and signs (new-onset fever, headache, nasal discharge) after five to six days * ”double worsening” or “double sickening” o Onset of severe symptoms (high fever->102°F, purulent nasal discharge or facial pain) for at least 3-4 consecutive days at the beginning of illness
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Acute Bacterial Rhinosinusitis (ABRS): risk factors
o chronic nasal congestion, o asthma, o cigarette smoking/exposure, o anatomical abnormalities (polyps, deviated septum)
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Acute Bacterial Rhinosinusitis (ABRS): common pathogen
strep pneumoniae
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Acute Bacterial Rhinosinusitis (ABRS): complications
o orbital/periorbital cellulitis, o osteomyelitis, o sinus thrombus, o intracranial/epidural abscess o meningitis
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Acute Bacterial Rhinosinusitis (ABRS): tx
o Many patients with ABRS have self-limited disease that resolves without antibiotic therapy! o Amox/clavulanate aka Augmentin o Amoxicillin * Due to antibiotic resistance you will often see Augmentin as 1st line, but Amoxicillin also used * For PCN allergy, doxycycline or third generation cephalosporin with or without clindamycin (due to resistance) * Duration of therapy: 5-7 days usually enough unless severe; more SE with 10 day treatment courses
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risk factors for resistance
o Age >/= 65 o Hospitalization in the last 5 days o Antibiotic use in the previous month o Immunocompromise o Multiple comorbidities o Severe infection o **1st line treatment in high risk patients: High dose Augmentin (2gm PO bid)
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indications for urgent referral
o Persistent high fevers o Abnormal vision/EOM o Change in mental status o Periorbital edema o Cranial nerve palsies o Meningeal signs
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influenza
acute respiratory infectio, a self-limiting virus
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infleunza A
Affects multiple species, including: o Humans o Swine o Equine o Birds
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influenza A transmission/incubation
o Large droplet transmission: * Inhalation of resp particles (cough, sneeze) o Small particle transmission: * Talking, exhalation o Fomite o Virus detectable & may shed in resp secretions up to 24 hours BEFORE sx onset o Incubation: * 24-48 hours
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s/s influenza A
o Abrupt onset! o Fever, chills, myalgias o Malaise, anorexia o Headache o Cough (dry) o Nasal congestion (clear) o Sore throat o Fever 100-104℉ o Convalescent phase: 1-2 weeks after acute febrile stage * Cough, malaise, fatigue o Some people can have mild illness like a cold Children: * Irritability, refusal to eat, rhinitis, GI sx like v/d Older adults: * Less likely to have those classic flus sx like younger individuals, may not have fever, anorexia, malaise, dizziness; * Higher morbidity/mortality
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influenza A: H & PE
o Diagnosis largely rests on history o Focused PE: * General survey, HEENT, cardiac, pulmonary o Clinical findings that may be present: * Fever likely * Skin: Hot/moist, flushed face * May have enlarged, tender cervical LN * Lungs typically clear
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diagnostics influenza
RT-PCR (most sensitive/specific) stick up the nose * Yields rapid results * Differentiates between influenza types/subtypes Rapid flu tests: * Distinguishes between A&B; <30 min results * Lower sensitivity than RT-PCR When should we test? * If the result will influence management decisions * However, testing should not delay initiation of treatment, if indicated
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tx for influenza
supportive therapy * analgesics * cough suppressants * decongestants * antihistamines * local anesthetics Antivirals * most commonly used: Oseltamivir (Tamiflu)
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who should receive antiviral tx?
* persons who are hospitalized * persons who have severe, complicated or progressive illness * other persons who are at high risk includng: * persons <2 and >65 * persons with chrominc pulmonary (including asthma), cardiovascular, renal, hepatic, hematological, metabolic, or neurologic * persons with immunosuppression * persons who are pregnant or postpartum * persons aged younger than 19 years who are receiving long-term aspirin therapy * native americans/alaskian natives * persons who have a BMI >/ 40 * residents of nursing homes and other chronic care facilities
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influenza prevention
All persons 6 months and older should be vaccinated annually, ideally by October
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influenza vaccine
The first time a child between ages 6 months and 8 years receives the flu vaccine TWO doses are required at least 4 weeks apart (cdc.gov)
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URI vs influenza
URI * no fever * no headache * general aches and pains is sometimes, mild * fatigue and weakness is sometimes, mild * no extreme fatigue * runny nose * sore throat * sneezing * cough * chest dicomfort is sometimes, mild * onset gradudal influenza * fever * headache * general aches and pain * fatigue and weakness * extreme fatigue * runny, stuffy nose * sneezing * chest discomfort * sudden onset * can lead to pneumonia and respiratory failure
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chemoprophylaxis
* Long term care facility – outbreaks; 2 lab confirmed cases within 72 hours in residents on the same unit * Chemoprophylaxis is recommended for all asymptomatic patients, and consider for certain staff, especially unvaccinated and recently vaccinated persons