Acute Phase Reactants Flashcards
1
Q
What induces APRs
A
IL-6, IL-1, TNF-a, and IFN-y
2
Q
Serum Amyloid A
A
Prolonged Elevation –> Amyloidosis
3
Q
C-reactive protein
A
Opsonin, Fixes complement, facilitates phagocytosis.
Measured clinically as ongoing inflammation
4
Q
Ferritin
A
Binds and sequesters iron. Inhibits microbial scavenging
5
Q
Fibrinogen
A
Coag factor. correlates with ESR
6
Q
Hepcidin
A
Prevents release of iron. Anemia of chronic disease
7
Q
Albumin
A
Negatively regulated. Conserves amino acids
8
Q
Transferrin
A
Internallized by macrophages. down regulated
