Acute Laminitis Flashcards
What are the risk factors for laminitis?
Sepsis and systemic inflammation (GI disease, pneumonis, septic metritis)
Endocrine disorders (PPID and EMS)
Mechanical overload
Access to pasture
What is the pathology that causes laminitis?
Failure of the attachment of the epidermal cells of the epidermal laminae to the underlying basement membrane of the dermal laminae
What signalment can predispose to laminitis?
Pony, spring/summer, female, increasing age, obesity, recent increase in body weight, recent new access to grass, increasing time since worming, insulin resistance
What are the three stages of laminitis? What occurs at each stage?
Developmental/prodromal - contact with trigger, lasts up to 72 hours, no clinical signs, when all changes occur
Acute laminitis - onset of clinical signs
Resolution or chronic laminitis
How is inflammation linked to the pathogenesis of laminitis?
Minimal neutrophil infiltration caused doubt but recent research shows abundant evidence of inflammatory changes
Mechanisms linking pasture consumption and lamellar inflammation not fully determined but systemic inflammation accompanying hindgut carbohydrate overload is thought to initiate lamellar inflammatory events
How is ECM degradation linked to the pathogenesis of laminitis?
Previously thought that dysregulation of MMPs was fundamental but now known not to be an initiating event
Laminar separation may occur following a failure of epithelial adhesion molecules
Dysregulation of cell adhesion is most likely caused by inflammatory and/or hypoxic cellular injury
What pathologic mechanisms associated with EMS could increase chance of laminitis?
Changes in insulin signalling
Inflammatory cytokines
Endothelial dysfunction caused by adipose tissue-derived mediators
Why do laminitis prone individuals become more at risk during spring and summer?
Strong positive relationship between pasture NSC content and circulating insulin concentrations, increased CHO consumption increases IR
Exacerbation of IR by increased CHO consumption during summer months => laminitis
What are the vascular events that occur in the early stages of laminitis?
Digital venoconstriction and consequent laminar oedema
What are the hypothesised causes of vascular events in laminitis?
Platelet activation and platelet-neutrophil activation causing release of 5-HT causing venoconstriction
Amines from hindgut fermentation of CHO are vasoactive
IR in other species alters endothelial function creating a pro-inflammatory condition leading to platelet and leucocyte activation, increased ET-1 and production of inflammatory mediators and oxidant stress
What are alterations in digital vascular haemodynamics associated with?
Inflammation, platelet activation, action of vasoactive amines absorbed from the intestinal tract
What are your aims in a suspected case of laminitis?
Make a definitive diagnosis
Determine the underlying cause
Determine if horse is likely to recover to expected level of soundness
What is diagnosis of laminitis made on?
Clinical signs
+/- radiography showing sunken/rotated pedal bone
+/- endocrine tests for PPID and EMS
What are the clinical signs of laminitis?
Lameness affecting two or more limbs Leaning back on heels Bounding digital pulses Increased hoof wall temperature Pain on hoof tester at the point of the frog Palpable depression at the coronary band
What radiographs are taken to diagnose laminitis?
Lateromedial radiographs of feet following good foot preparation
Mark feet with one mark on dorsal hoof wall and one at the point of the frog