Acute Kidney Injury Flashcards
What does AKI stand for?
Acute kidney injury
What is the definition of acute kidney injury?
Increase in SCreatinine:
- By 26.5umol/L or more within 48 hours or
- To 1.5x baseline, which is known or presumed to have occurred within the 7 prior days or
- Urine volume <0.5ml/kg/h for 6 hours
What many stages of acute kidney injury are there?
3
What is the serum creatinine and urine output for AKI stage 1?
What is the serum creatinine and urine output for AKI stage 2?
What is the serum creatinine and urine output for AKI stage 3?
What does the immediately dangerous consequences of AKI depend on?
The immediately dangerous consequences of AKI depend on cause to an extent at least in the first few hours:
- Acidosis
- Electrolyte imbalance
- Intoxication toxins
- Overload
- Uraemic complications
What can the causes of AKI be classified into?
Pre-renal
Intrinsic (renal)
Post-renal
What are the normal functions of the kidneys?
Body fluid homeostasis
Regulation of vascular tone
Excretory function
Electrolyte homeostasis
Acid/base homeostasis
Endocrine function
What are possible bad short term and intermediate/long term complications of AKI?
- Short term (in hospital)
- Death, dialysis, length of stay
- Intermediate/long term (post-discharge)
- Death, CKD, dialysis, CKD related CV elements
How does mortality change with the stage of AKI?
Mortality increases with stage
What are pre-renal causes of AKI?
- Cardiac failure
- Haemorrhage
- Sepsis
- Vomiting and diarrhoea
What are renal causes of AKI?
- Glomerulonephritis
- Vasculitis
- Radiocontrast
- Myeloma
- Rhadomyolysis
- Drugs
- NSAIDs, gentamicin
What are post renal causes of AKI?
- Tumours
- Prostate disease
- Stones
What ar esome causes of AKI?
Pre-renal:
- Cardiac failure
- Haemorrhage
- Sepsis
- Vomiting and diarrhoea
Post-renal
- Tumours
- Prostate disease
- Stones
Intrinsic:
- Glomerulonephritis
- Vasculitis
- Radiocontrast
- Myeloma
- Rhadomyolysis
- Drugs
- NSAIDs, gentamicin
What are examples of drugs that can cause AKI?
NSAIDs
Gentamicin
How is AKI prevented?
By identifying patients who are at risk
(presence of risk event or risk factor)
What are examples of AKI risk events?
Sepsis (such as pneumonia, cellulitis, UTI)
Toxins (such as x-ray contrast, NSAIDs, gentamicin, herbal medicine)
Hypotension
Hypovolaemia (such as haemorrhage, vomiting, diarrhoea)
Major surgery
What are some risk factors for AKI?
Age > 75
Previous AKI
Heart failure
Liver disease
Chronic kidney disease
DM
Vascular disease
Cognitive impairment
What is the protocol when identifying patients at risk of AKI?
In presence of risk event or factor consider:
- treat sepsis if present
- avoid toxins
- optimise BP and volume status
- prevent harm
Much of AKI is avoidable, how can it be prevented?
- Avoid dehydration
- Avoid nephrotoxic drugs
- Review clinical status in those at risk and act on findings
What are medicine “sick day rules”?
When you have vomiting or diarrhoea (unless only minor) or fever, sweats and shaking you stop taking certain medications
Restart medications when well (24-48 hours after eating and drinking normally)
When should medicines be restarted after “sick day” rules?
- Restart medications when are well (after 24-48 hours of eating and drinking normally)
What are exampls of medications that should be stopped on “sick days”?
- ACE inhibitors
- ARBs
- NSAIDs
- Diuretics
- Metformin
