Acute and chronic pancreatitis Flashcards
Endocrine function of pancreas
produce insulin and glucagon
Exocrine function of pancreas
secrete enzymes
lipase and amylase
Reversible inflammatory process of pancreatic acini
acute pancreatitis
Cause of inflammatory process of acute pancreatitis
premature activation of pancreatic enzymes
the enzymes digest pancreatic tissue and blood vessels
Progressive and permanent destruction of exocrine pancreas
chronic pancreatitis
Fourth leading cause of cancer death in US
pancreatic tumors
s/sx acute pancreatitis
midepigastric or flank pain
n/v
Acute pancreatitis is associated with
alochol abuser
cholelithiasis
Complications of acute pancreatitis
vascular shock renal failure ARDS-aspiration of enzymes fat necrosis malabsorption
True or false: acute pancreatitis can have widespread effects on other body systems
true
GI effects of acute pancreatitis
Premature enzyme activation
elastase-hemmorhage
phospholipase A- cell membrane digestion
fluid losses-hypovolemic shock
Cardiovascular effects of acute pancreatitis
tyrpsin activates kallidrein
vasodilation
increased vascular permeability
fluid losses
Clotting system effects of acute pancreatitis
inflammation interferes with vitamin K absorption
clotting factor production reduced
DIC
Immune effects of acute pancreatitis
infection of pancreas
purulent drainage can erode through retroperitoneum
Respiratory effects of acute pancreatitis
pain interferes with breathing-pneumonia
ARDS from pancreatic enzymes
pleural effusion from pulmonary vessel damage
