ACTIVITY 1 Flashcards
blockade of neuronal T-type Ca2+ channel
valproic acid
GABAA receptor–chloride ion channel macromolecular complex (opening of Cl channel) Increase duration
clonazepam and benzodiazepines
GABAA receptor–chloride ion channel macromolecular complex (opening of Cl channel) Increase frequency
phenobarbital and barbiturates
(TCA) = inhibits re-uptake of NE and 5-HT
Clomipramine
(heterocyclics) = inhibits re-uptake of NE and 5-HT
Duloxetine
(heterocyclics) = α2-receptor antagonism
Mirtazapine
(SSRI) = inhibits re-uptake of 5-HT
Fluoxetine
(TCA) = inhibits re-uptake of NE and 5-HT
Trimipramine
inhibit protein synthesis by binding, with high affinity, to the A-site on the 16S ribosomal RNA of the 30S ribosome
Aminoglycosides
reversibly inhibit nerve transmission by binding voltage-gated sodium channels (Nav) in the nerve plasma membrane
Local anesthetics
inhibit synaptic activity partly through direct activation of μ, δ, and κ receptors that confers antinociceptive mechanisms at the spinal level.
Opioid analgesics
a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy.
Pregnancy category
Fetal risks are evident; there are no situations where the risk/benefit justifies use
Pregnancy Category X
Insufficient human studies, but animal studies show problems or: No animal studies, and insufficient human studies
Pregnancy Category C
Appropriate human studies - no risk
Pregnancy Category A
Human studies, with/without animal research show fetal risks, but the drug is important to some women to treat their conditions
Pregnancy Category D
Insufficient human studies, but animal research suggests safety or: Animal studies show issues but human studies show safety
Pregnancy Category B
a solid dosage form containing medicinal substance(s) with or without diluents.
Tablet
a solid dosage form in which the drug is enclosed within a hard or soft soluble container or shell.
Capsule
drug in the form of a capsule prepared in such a way that, when taken orally, its contents are released slowly
Spansules
tablet dosage form in the shape of a capsule.
Caplet
a two-phase system in which one liquid is dispersed throughout another liquid in the form of small droplets.
Emulsion
a solution containing a high concentration of sucrose or other sugars
Syrup
a liquid preparation that consists of solid particles dispersed throughout a liquid phase in which the particles are not soluble; it may be oral, topical, otic, or ophthalmic.
Suspension
