Action Potential and Neurons Flashcards
Sodium Potassium Pump
Pumps 3 Na+ into the cell and 2 K+ out of the cell
Helps restore neuron to -70mV while at rest
Pump moves ions against concentration gradient (Uses ATP)
Leakage Channels
K+ leakage channels allow K+ to move passively in and out of a cell to reach a voltage of -70mV
This is operational at rest
Connection point between two neurons
Synapse
Connection point between a nerve and a muscle
Neuromuscular Junction
Types of channels in neuron membrane
Chemically gated
Voltage gated
Leak Channel
Potassium/Sodium pump
Chemically gated channel
Opens when a chemical binds with the door of the gate
Voltage gated channel
Opens when a certain voltage (Threshold) is reached
What voltage opens K+
+30mV
What voltage opens Na+
-55mV
What are the principles of Electricity
Voltage
Current
Resistance
Voltage
The separation of charge inside and outside a cell
Current
The movement of ions into and out of a cell
Resistance
The cell membrane inhibiting movement of ions
This is changed when a channel is opened
EPSP
Excitatory post synaptic potential
IPSP
Inhibitory post synaptic potential
What does EPSP do
Moves a neuron closer to threshold (-55mV)/ Makes cell less negative inside
(EX: moving Na+ into the cell)
What does IPSP do
Moves the neuron further away from threshold/Makes the inside of a cell more negative
(EX: adding Cl- to a cell)
Types of graded potentials
EPSP
IPSP
Phases of Action Potential
Depolarization
Repolarization
Hyperpolarization
Depolarization
Chemically gated Na+ channel opens allowing Na+ to rush into cell causing voltage to become less negative. Once voltage reaches -55mV voltage gated Na+ channels open allowing even more Na+ to enter the cell. This brings voltage closer together on inside and outside of a cell until it reaches +30mV in and out
Repolarization
Once +30mV is reached Na+ channels close and K+ channels open allowing K+ to flow out of the cell bringing the negativity inside the cell back down. This helps return the voltage in the cell back to -70mV
Hyperpolarization
K+ channels are slow to close which allows excess flow of K+ out of a cell. This can cause the voltage to exceed -70mV
This requires a stronger graded potential in order to generate another action potential
Refractory Periods
Absolute
Relative
Absolute Refractory Period
No stimuli can generate another action potential (While axon is firing)
Relative Refractory Period
Another Action potential is possible, but it will need to overcome hyperpolarization
Determining weak vs. strong stimuli
ALL ACTION POTENTIALS HAVE THE SAME STRENGTH
strength of stimulus is based on frequency of action potential (whether or not a stimulus can overcome hyperpolarization or wait for normal polarization)
Divisions of the nervous system
Central Nervous System
Peripheral Nervous System
CNS
Brain and Spinal Cord
PNS
Cranial nerves and spinal nerves