Action Potential and Neurons Flashcards
Sodium Potassium Pump
Pumps 3 Na+ into the cell and 2 K+ out of the cell
Helps restore neuron to -70mV while at rest
Pump moves ions against concentration gradient (Uses ATP)
Leakage Channels
K+ leakage channels allow K+ to move passively in and out of a cell to reach a voltage of -70mV
This is operational at rest
Connection point between two neurons
Synapse
Connection point between a nerve and a muscle
Neuromuscular Junction
Types of channels in neuron membrane
Chemically gated
Voltage gated
Leak Channel
Potassium/Sodium pump
Chemically gated channel
Opens when a chemical binds with the door of the gate
Voltage gated channel
Opens when a certain voltage (Threshold) is reached
What voltage opens K+
+30mV
What voltage opens Na+
-55mV
What are the principles of Electricity
Voltage
Current
Resistance
Voltage
The separation of charge inside and outside a cell
Current
The movement of ions into and out of a cell
Resistance
The cell membrane inhibiting movement of ions
This is changed when a channel is opened
EPSP
Excitatory post synaptic potential
IPSP
Inhibitory post synaptic potential
What does EPSP do
Moves a neuron closer to threshold (-55mV)/ Makes cell less negative inside
(EX: moving Na+ into the cell)
What does IPSP do
Moves the neuron further away from threshold/Makes the inside of a cell more negative
(EX: adding Cl- to a cell)
Types of graded potentials
EPSP
IPSP
Phases of Action Potential
Depolarization
Repolarization
Hyperpolarization
Depolarization
Chemically gated Na+ channel opens allowing Na+ to rush into cell causing voltage to become less negative. Once voltage reaches -55mV voltage gated Na+ channels open allowing even more Na+ to enter the cell. This brings voltage closer together on inside and outside of a cell until it reaches +30mV in and out
Repolarization
Once +30mV is reached Na+ channels close and K+ channels open allowing K+ to flow out of the cell bringing the negativity inside the cell back down. This helps return the voltage in the cell back to -70mV
Hyperpolarization
K+ channels are slow to close which allows excess flow of K+ out of a cell. This can cause the voltage to exceed -70mV
This requires a stronger graded potential in order to generate another action potential
Refractory Periods
Absolute
Relative
Absolute Refractory Period
No stimuli can generate another action potential (While axon is firing)