ACT NO. 8: Assay of Antacid Tablet Flashcards
Acid is secreted by ___________ in the proximal two thirds (body) of the stomach.
parietal cells
Aids digestion by creating the optimal pH for pepsin and gastric lipase and by stimulating pancreatic bicarbonate secretion.
Gastric acid
When there is an excess of the acid, ______________ results.
hyperacidity
Therefore, in order to counteract excess acid and make it more neutral, ____________ are commonly used.
antacids
This assay is important in order to determine the relative effectiveness of several commercial preparations in neutralizing stomach acid, in terms of the amount of acid consumed per antacid tablet.
Importance of the Assay of Antacid tablets (ANC)
ANC measures the ability of the antacid to neutralize acids (pH of ___________).
3.5 to 4
The US FDA requirement is that an antacid must have a neutralizing capacity of ?
≥ 5 mEq per dose
Residual Titration
These are drugs that neutralize excess gastric acids.
Antacids
Some antacids also contain _____________, an ingredient that helps the body get rid of gas.
simethicone
Some antacids contain ingredients that can cause diarrhea, such as _______________, or constipation, such as ______________.
diarrhea - magnesium
constipation - aluminum
Antacids relieve symptoms that can cause heartburn and indigestion including:
• A burning sensation in the chest or stomach, especially after eating or at night.
• An acidic or sour taste in the mouth.
• Feeling full or bloated.
• Mild pain in the chest and stomach.
This is usually performed using same process as a conventional the titration. Titrant of known concentration which is filled in the burette is titrated with the solvent that has ZERO analytes which are poured in the conical flask.
Blank Titration
Residual Titration is also known as?
Back Titration
Frequently used when a reaction proceeds slowly or when the substance to be assayed does not give a distinct, sharp end point with an indicator by direct titration.
Residual Titration
