ACT NO. 5: Preparation and Standardization of Volumetric Solutions

Question 1

Volumetric Analysis is also known as?

Answer 1

Titrimetric Analysis

Question 2

Volumetric Analysis is first introduced by ?

Answer 2

Jean Baptiste Andre Dumas (French chemist)

Question 3

Volumetric Analysis’ type of analysis

Answer 3

Quantitative Analysis

Question 4

Based on the determination of the VOLUME of a solution of known concentration (standard) required to react quantitatively with a solution of the substance to be analyzed.

Answer 4

Volumetric Analysis

Question 5

Volumetric solution is also known as?

Answer 5

Titrant / Standard Solutions

Question 6

Known concentration

Answer 6

TitranT

Question 7

Unknown concentration

Answer 7

Analyte

Question 8

One of the simplest and oldest method of quantitative analysis.

Answer 8

Titration

Question 9

Wherein, the amount of pure substance determined is by quantitatively reacting with the titrant or also known as volumetric solution.

Answer 9

Titration

Question 10

Abbreviated “VS” and known also as Standard Solutions, are solutions of reagents of known concentration intended primarily for use in quantitative determinations.

Answer 10

Volumetric Solutions

Question 11

Abbreviated “TS,” are solutions of reagents in such solvents and of such definite concentrations as to be suitable for the specified purposes.

Answer 11

Test Solutions

Question 12

Indicators are ________ agents used to determine the end point of titration.

Answer 12

auxiliary agents

Question 13

A species added to the analyte to give an observable change at (which is the endpoint) or near the end point.

Answer 13

Indicators

Question 14

Meets the minimum purity standards; conforms to tolerances set by the United States Pharmacopeia/National Formulary for contaminants dangerous to health.

Answer 14

USP/NF

Question 15

High purity; conforms to minimum specifications set by the Reagent Chemicals Committee of the American Chemical Society

Answer 15

ACS reagent (American Chemical Society)

Question 16

More refined than technical or commercial grade but still of unknown quality

Answer 16

CP (chemically pure)

Question 17

Indeterminate quality

Answer 17

Technical or commercial

Question 18

A process of determining exact concentration of a solution.

Answer 18

Standardization

Question 19

A highly pure and stable chemical reagent used to prepare standard solutions, usually for titration and making secondary standards and dilutions.

Answer 19

Primary Standard

Question 20

Properties of Primary Standard:

Answer 20

HIGH PURITY

STABLE IN AIR

INDEPENDENT OF RELATIVE HUMIDITY

READILY AVAILABLE

REASONABLE SOLUBILITY

LARGE FORMULA WEIGHT

Question 21

An alternative method is by the use of a solution of known concentration and allowing it to react equally with the prepared solution which is called as the ?

Answer 21

Secondary Standard

Question 22

A highly characterized material suitable to test the identity, strength, quality and purity of substances for pharmaceutical use and medicinal products.

Answer 22

Reference Standard

Question 23

Standard Solutions examples

Answer 23

• Perchloric acid
• Sodium methoxide
• Silver nitrate
• Ammonium thiocyanate
• Potassium permanganate
• Oxalic acid
• Ceric sulfate
• Zinc sulfate
• EDTA
• lodine
• Sodium thiosulfate

Question 24

This is primarily used for analysis, product development, and quality control.

Answer 24

Titrimetric and chemical analysis methods

Question 25

Certain specialist titrations, such as the KARL FISCHER titration used to estimate ___________, are widely used in the pharmaceutical industry.

Answer 25

water content

Question 26

The desired end point in a phenolphthalein titration is ?

Answer 26

A pale pink tint that persists for 30 seconds.

Question 27

KSCN may replace ?

Answer 27

NH4SCN

Question 28

• Ammonium sulfocyanate
• Hygroscopic, crystalline solid
• Reacts with several metals

Answer 28

NH4SCN

Question 29

MW of NH4SCN

Answer 29

76.122g/mole