Acne

Question 1

What is the pathophys of acne?

Answer 1

Increased sebaceous gland sensitivity to androgens leads to basal keratinocyte proliferation and increased sebum production.

Inflammation and colonisation by P acnes bacteria leads to formation of papules, pustules, and comedones.

Question 2

How is acne treated?

Answer 2

Mild: topical steroids and retinoids e.g. benzoyl peroxide.

Moderate: topical or oral antibiotics e.g. erythromycin, clindamycin.

Severe: oral isotretinoin

Question 3

Main complication of isotretinoin?

Answer 3

Teratogenic, so girls should be on dual contraceptive e.g. pill and condom.