ACLS Pharmacology Flashcards

know all the drugs from the ACLS book

1
Q

This drug is the first used for most forms of stable narrow-complex SVT and is effective in terminating those due to reentry involving AV node or sinus node.

A

Adenosine

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2
Q

is Adenosine safe and effective in pregnancy?

A

Yes

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3
Q

when is adenosine contraindicated?

A

in poison or drug induced tachycardia or second- or third-degree heart block

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4
Q

what are the side effects of adenosine?

A

flushing, chest pain or tightness, brief periods of asystole or bradycardia, ventricular ectopy

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5
Q

what is a common thing to see after giving adenosine?

A

transient periods of sinus bradycardia and ventricular ectopy are common after termination of SVT

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6
Q

what are the steps taken when pushing adenosine?

A
  • place the patient in mild Trendelenburg
  • initial bolus of 6 mg given rapidly over 1 to 3 seconds followed by NS bolus of 20 ml, then elevate the extremity
  • a second dose can be given in 1 to 2 minutes if needed
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7
Q

what should you be doing as you are giving adenosine?

A

record a rhythm strip

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8
Q

what is the half life of amiodarone?

A

40 days

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9
Q

when is amiodarone indicated?

A

VF/ pulseless VT unresponsive to shock delivery, CPR, and a vasopressor
- recurrent, hemodynamically unstable VT

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10
Q

amiodarone used for VF/ pVT cardiac arrest unresponsive to shock, CPR, and Vasopressor, what would be the first dose?

A

300 mg IV/IO push for the first dose

- if a second dose is needed, 150 mg IV/IO push

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11
Q

amiodarone used for life threatening arrhythmias, what is the maximum dose?
Rapid
Slow
Maintenance

A

2.2 g IV over 24 hours.
Rapid - 150 mg IV over 10 minutes (150 mg Q 10 min)
Slow - 360 mg IV over 6 hours (1 mg per minute)
Maintenance - 540 mg IV over 18 hours (0.5 mg per minute)

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12
Q

How can some drugs be given if you don’t have IV access

A

The endotracheal (ET) route for drug delivery may be used when a life-threatening or serious condition requires immediate drug intervention, but intravenous or intraosseous access is not readily available

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13
Q

what are the two acronyms for drugs that can be given via ET tube
adults and peds

A

adults - NAVEL
Peds - LEAN
Naloxone, atropine, Vasopressin (adults only), epinephrine, Lidocaine

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14
Q

what is the first line drug for symptomatic sinus bradycardia?

A

atropine

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15
Q

when is atropine unlikely to be effective?

A

Type II second degree or third degree AV block in nonmodal tissue

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16
Q

what is something to consider when using atropine in the presence of myocardial ischemia and hypoxia?

A

it increases myocardial O2 demand

17
Q

what may be the effect of using a dose of atropine that is less than 0.5 mg?

A

may cause paradoxical slowing of the heart

18
Q

what is the recommended dose of atropine for bradycardia?

A

0.5 mg IV Q 3 to 5 minutes PRN, not to exceed a total dose of 0.04 mg per kg (total 3 mg)

19
Q

when would you use a lager dose of atropine (2 to 4 mg or higher)

A

in a case of Organophosphate Poisoning, or nerve agent

20
Q

what is the second line drug for symptomatic bradycardia?

A

Dopamine

after atropine

21
Q

aside from being the second line drug after atropine, when would you use Dopamine?

A

for hypotension with SBP >70 - 100 mmHg with signs and symptoms of shock

22
Q

what are 4 contraindications/ considerations when administering Dopamine?

A
  • correct hypovolemia with volume replacement before using
  • use with caution with cardiogenic shock with CHF
  • May cause tachyarrhythmias, excessive vasoconstriction
  • do not mix with sodium Bicarb
23
Q

what is the typical IV administration of Dopamine?

A

2 to 20 mcg/kg per minute, titrate to patient response and taper slowly

24
Q

what are the 4 indications for epinephrine listed in the ACLS book?

A

cardiac arrest with VF, pulseless VT, asystole, PEA

  • Symptomatic bradycardia can be considered after atropine as an alternative infusion to dopamine
  • Severe hypotension; can be used when pacing and atropine fail, when hypotension accompanies bradycardia, or with phosphodiesterase enzyme inhibitor
  • Anaphylaxis, severe allergic reactions; combine with large fluid volume, corticosteroids, and antihistamines
25
Q

what are some contraindications/ precautions for epinephrine?

A

raising BP and HR may increase O2 demand on myocardium

  • higher doses do not improve survival outcomes and may contribute to post resuscitation myocardial dysfunction
  • higher doses may be required to treat poison/ drug induced shock
26
Q

epinephrine used for cardiac arrest, what is the dose?

A

IV/IO dose; 1 mg (10 ml 0f 1:10,000 solution) administered Q 3 to 5 minutes during resuscitation. Follow each dose with 20 ml flush, elevate arm for 10 to 20 seconds after dose

27
Q

when would a higher dose of epinephrine be warranted?

A

higher doses (up to 0.2 mg/kg) may be used for specific indications such as B-blocker or calcium channel blocker overdose)

28
Q

what would the dose for epinephrine be for continuous infusion?

A

Initially 0.1 to 0.5 mcg/kg per minute (for 70 kg patient; 7 - 35 mcg per minute) titrate response

29
Q

what would the dose be for epinephrine given the endotracheal route?

A

2 to 2.5 mg diluted in 10 ml NS

30
Q

what drug can be used as an alternative to amiodarone in cardiac arrest from VF/pVT?

A

Lidocaine

31
Q

what are the 4 indications for using Lidocaine as per the ACLS manual?

A
  • stable monomorphic VT with preserved ventricular function
  • stable polymorphic VT with preserved LV function when ischemia is treated and electrolyte balance is corrected
  • can be used for polymorphic VT with baseline
  • QT interval prolongation if torsades suspected
32
Q

what are the doses used for Lidocaine in cardiac arrest from VF/pVT

A

initial dose; 1 to 1.5 mg/kg IV/IO
- for refractory VF, may give an additional 0.5 to 0.75 mg/kg IV push, repeat in 5 to 10 minutes; max dose 3 doses or total 3mg/kg

33
Q

what would the dose be for a maintenance infusion of Lidocaine?

A

1 to 4 mg per minute (30 to 50 mcg/kg per minute)

34
Q

when is magnesium used in cardiac arrest

A

torsades or suspected hypomagnesemia

35
Q

aside from cardiac arrest, what are the indications for using magnesium sulfate as stated in the ACLS manual

A

life - threatening ventricular arrhythmia due to digitalis toxicity

36
Q

what are some contraindications/ considerations for using magnesium sulfate?

A

occasional fall in blood pressure with rapid administrations

- Use with caution if renal failure if present.

37
Q

what are the doses for administering Magnesium sulfate in cardiac arrest (due to hypomagnesemia or Torsades de Pointes)?

A

1 to 2 g (2 to 4 ml of a 50% solution diluted in 10 ml (eg D5W or NSS) given IV/IO)

38
Q

what are the doses for magnesium sulfate used to treat Torsades de Pointes with a pulse or AMI with hypomagnesemia?
what is the loading dose and what do you follow with?

A

loading dose of 1 to 2 g mixed in 50 to 100 ml of dilutent over 5 to 60 minutes IV
- follow with 0.5 to 1 g per hour IV (titrate to control TdP)