Acid Base Flashcards
Mechanisms in H regulation
Chemical Buffering
Alveolar ventilation
H excretion
Donate H ions
Acid
Receive/accept H ions
Base
Completely ionized acid
Ka
strong acid
high Ka
principal buffers in the body
weak acid
Henderson Hasselbach equation
pH = pKa + log (base/acid)
prevent large changes in H concentration
Buffers
Buffer is most efficient whrn pH of the solution is within ___ unit of its pKa
+-1.0 pH
principal extracellular buffer
Hco3/Co2
Intracellular and Bone buffers
proteins, PO4-, hgb
Immediate response to acid and base loads
chemical buffering
Respiratory acidosis compensation
For every 10 mmHg increase in Pco2, inc in plasma Hco3 1-3.5 mmol/L
Most effective defense of respiratory acidosis
inc in bicarbonate concentration
enhanced renal H excretion