ACHEM Selecting Analytical Method

Question 1

Ratio for the change in amount of unit to the change in signal intensity. It is the measure of a methods ability to distinguish between two samples

Answer 1

Calibration sensitivity (m)

Question 2

Lowest concentration or absolute amoujt of analyte that has a signal larger than the signal from the suitable blank

Answer 2

Detection limit

Question 3

The number of analyses of similar types which have to be performed
To be Consider or not

Answer 3

To be consider

Question 4

Defined as the fraction of the named material present in the stated chemical form

Answer 4

Purity

Question 5

These aee acceptable food, drug or medicinal use, they also meets or EXCEEEDS requirements set by the National Formulary

Answer 5

NF national Fomulary

Question 6

Problems arising from the nature of the target material including its radioactivity corrosiveness hygroscopicity etc is being considered un selecting analytical method

Answer 6

True

Question 7

Have the highest purity chemical hrade with greater than or less than 95% and are strictly use for quality specifications

Answer 7

ACS american chemical society

Question 8

Possible interferences, concentration range, availability of facilities, time required for analysis, and the number of analyses os same type is being considered in selecting analytical method

Answer 8

True

Question 9

Possible interferences, concentration range, availability of facilities, time required for analysis, and the number of analyses os same type is being considered in selecting analytical method

Answer 9

True

Question 10

Refer to how clear a signal is relative to how noisy these random fluctuations are also the magnitude of the background divided by the sd of the background signal

Answer 10

Signal to noise ratio

Question 11

______ of an analytical method is ____ if its signal depends only on the analyte (one component only)

Answer 11

Specificity, specific

Question 12

This meets or exceeds requirements set by the pharmacopeia and are accepted for food, drug, or medicinal use

Answer 12

US united states pharmacopeia

Question 13

Determines the materials purity

Answer 13

Grade

Question 14

1.Degree of sophistication
2.
3.
4.cost
5. Time requirements

Answer 14

Selectivity and sensitivity

Question 15

Have relatively high quality with exact levels of impurities known often usedfor general work where Analytical Reagent is not required

Answer 15

Laboratory grade

Question 16

State the 6 grades of chemicals

Answer 16

ACS
AR
USP
National formulary
Laboratory
Technical or commercial

Question 17

This grade is for low grade applications for qualitative testing and often supplied in bulk having purity of less than 90%

Answer 17

Technical or commercial

Question 18

This grade is for low grade applications for qualitative testing and often supplied in bulk having purity of less than 90%

Answer 18

Technical or commercial

Question 19

The grade and purity of chemicals have siginificant effect in analysis that why it needs to be _______ with intended purpose

Answer 19

Consistent

Question 20

Example of technical or commercial grade chemicals

Answer 20

Methanol
Sodium carbonate or baking soda

Question 21

Example of technical or commercial grade chemicals

Answer 21

Methanol
Sodium carbonate or baking soda

Question 22

3rd stanndarr where generally ang globally recognised standard employed by testing and calibration lab provides technical competence to perform particular tests

Answer 22

ISO/IEC 17025:2005

Question 23

A protocol that requires all the organizations manufacturing products for human consumption to be safe pure and effective

Answer 23

GMP or cGMP

Question 24

These serves as a means of evaluating the current performance of the method being used and this is desribed as a parameter to ensure the quality of individual or batch result of the laboratory activities

Answer 24

QC in Laboratories

Question 25

Also known as check sample, Samples of known composition having similar matrix and analyte concentration to the samples to be analysed,

Answer 25

QC samples

Question 26

It needs to be close as possible in composition to the samples but without the analyte present

Answer 26

Blank

Question 27

Protocol required for all analytical lab which is concerned in overall process in lab from planning, execution, recording. A sebsection of GMP

Answer 27

GLP

Question 28

Promofes adoption of a process approach when developing, implementing, and imporoving the effectiveness of a QMS

Answer 28

ISO 9000 QMS

Question 29

Medical laboratory should abide

Answer 29

ISO 15189

Question 30

This is known as fortification which involves adding a known quantity of analyte to a sample to test whether the response to a sample is the same as that of expected from calibration curve.

Answer 30

Spike

Question 31

These are blank similat to a method blank where in sample containing all components except abalyte is taken through all steps of analytical procedures but also it has been exposed to site of sampling and aew subjected to all possible sources of contamination.

Answer 31

Field blank

Question 32

These sanples provide less formal check than conventional QC samples and usually repeated later in the batch of samples or in different batch. This variation between is then studied and must be within the acceptable limit

Answer 32

Repeat sample

Question 33

This samaples are not been subjected to all sample preparation procedure

Answer 33

Reagent blank

Question 34

Samples inserted into analytical batch without knowledge of analyst

Answer 34

Blind samples

Question 35

Method blank is that a sample containing _______ except analyte is taken through _____ of the process

Answer 35

All components, all steps

Question 36

A good qc sample must have
1.Fully characterized in house or by third part
2. Similar in composition to the types of samples normally required
3. _____; homogenous; available in _____ quantities because they are repeatedly examined.

Answer 36

Stable, large