Acetylcholine Flashcards
All PNS motor neurons release ACh except
postganglionic sympathetic neuron (except sweat glands)
ACh is synthesized from
Acetyl CoA and Choline
What is the name of enzyme that use to synthesize ACh ?
acetyltransferase
What is the rate limiting step of ACh synthesis?
the availability of choline and acetyl-CoA.
AChesterase can’t degrade ACh if
Ach is vesicle-bound
ACh is transported from cytoplasm into vesicle by what carrier protein?
VAChT( Vesicular ACh transporter)
The release of ACh from vesicle into synaptic cleft is triggered by Calcium. T/F?
T
Where are nicotinic receptors located at?
Nm: skeletal muscle
Nn: postganglionic neuronal cell bodies
Adrenal medulla(chromaffin cell)
M2 primarily located at
heart
M1 primarily located at
neural e.g. autonomic ganglia, glands, cerebral cortex
M3 located at
GIT, RT, exocrine glands, pupil,blood vessel,smooth muscle
Which receptor is ligand gated ion channel?
nicotinic
Which receptor is GPCR?
muscarinic
What happens when vesamicol is taken?
VAChT is blocked, thus preventing ACh from being stored in vesicle
What VAMPs (vesicle-associated membrane proteins) do?
aligns the vesicle to the release site of the inner surface of the nerve terminal and involve in triggering the release of ACh
