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2. Enfermedades inflamatorias > ACETATO DE METILPREDNISOLONA > Flashcards

ACETATO DE METILPREDNISOLONA Flashcards

1
Q

MECANISMO DE ACCIÓN

A

Glucocorticoide antiinflamatorio. Síntesis de macrocortina, inhibiendo la actividad de Fosfolipasa A2 y por consiguiente la liberación de ácido araquidónico.

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2
Q

INDICACIONES CLÍNICAS

A

Insuficiencia suprarrenal, asma, crisis reumática aguda, reacciones alérgicas graves.

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3
Q

FARMACOCINÉTICA: Administración

A

Oral.

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4
Q

FARMACOCINÉTICA: Absorción

A

Buena.

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5
Q

FARMACOCINÉTICA: Distribución

A

1.5 L/kg.

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6
Q

FARMACOCINÉTICA: Metabolismo

A

Hepático.

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7
Q

FARMACOCINÉTICA: Excreción

A

Renal.

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8
Q

FARMACOCINÉTICA: V ½ E

A

2-3 horas.

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9
Q

REACCIONES ADVERSAS

A

Nerviosismo, insomnio, dolor muscular.

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10
Q

INTERACCIONES RELEVANTES:

A

El uso concomitante de aspirina y corticosteroides aumenta el riesgo de ulceración gastrointestinal.

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11
Q

PRECAUCIONES Y CONTRAINDICACIONES RELEVANTES

A

No administrar en caso de infecciones sistemicas fúngicas.

Categoría del embarazo: C.

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2. Enfermedades inflamatorias (19 decks)

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