Acetaminophen

Question 1

Empiric acetylcysteine for what IV acetaminophen dose?

Answer 1

> 60mg/kg

Or >50 mcg/ml on nomogram at 4 hours

Question 2

standard regimen for IV acetylcysteine uses a 21-hour protocol which is:

Answer 2

loading dose of 150 milligrams/kg over 1 hour,

first maintenance dose of 50 milligrams/kg infused over 4 hours,

second maintenance dose of 100 milligrams/kg infused over 16 hours

Question 3

acetylcysteine averts toxicity by what MOA:

Answer 3

preventing the binding of NAPQI to hepatic macromolecules

act as a glutathione precursor or substitute, or a sulfate precursor, or it may directly reduce NAPQI back to acetaminophen

Question 4

nomogram only directly applies
to an acetaminophen concentration obtained after

Answer 4

1. single oral exposure

and

2. window between 4 hours and 24 hours
   after ingestion

Question 5

standard regimen for IV acetylcysteine uses a 21-hour protocol

Answer 5

loading dose of 150 milligrams/kg over 1 hour,

first maintenance dose of 50 milligrams/kg infused over 4 hours,

second maintenance dose of 100 milligrams/kg
infused over 16 hours