Antipsychotics

Question 1

rare but potentially fatal idiosyncratic complication of antipsychotic drug therapy and NOT the result of an overdose

Answer 1

Neuroleptic malignant syndrome

Question 2

Neuroleptic malignant syndrome typically develops over a period of _______ days

Answer 2

1 to 3 days

Question 3

Tetrad of neuroleptic malignant syndrome

Answer 3

ARFS

altered mental status, muscular rigidity, fever, and sympathetic nervous system lability.

Question 4

In addition to the tetrad, two other features embody important concepts about this syndrome:

Answer 4

recent dopamine antagonist exposure or

dopamine agonist withdrawal and

negative evaluation for other causes

Question 5

Common laboratories seen in neuroleptic malignant syndrome

Answer 5

elevated creatine kinase level, leukocytosis, elevated levels of hepatic transami- nases, hypernatremia or hyponatremia, metabolic acidosis, myoglobin- uria, elevated BUN and creatinine levels, and decreased serum iron level.