acanthosis nigricans Flashcards
classification
Type 1: Hereditary Benign AN. No associated endocrine disorder.
Type 2: Benign AN. Endocrine disorders associated with insulin resistance: insulin- resistant type II diabetes mellitus, hyper- androgenic states, acromegaly/gigantism, Cushing disease, hypogonadal syndromes with insulin resistance, Addison disease, and hypothyroidism.
Type 3: Pseudo-AN. Associated with obesity; more common in patients with darker pig- mentation. Common in metabolic syndrome. Obesity produces insulin resistance.
Type 4: Drug-Induced AN. Nicotinic acid in high dosage, stilbestrol in young males, gluco- corticoid therapy, diethylstilbestrol/oral con- traceptive, and growth hormone therapy.
Type 5: Malignant AN. Paraneoplastic, usually adenocarcinomao gastrointestinalorgenito- urinary tract; less commonly, bronchial carci- noma and lymphoma.
