Acanthosis nigricans Flashcards
1
Q
what are they?
A
symmetrical brown, velvety plaques
found on the neck, axilla and groin
2
Q
causes
A
type 2 diabetes mellitus
gastrointestinal cancer
obesity
polycystic ovarian syndrome
acromegaly
Cushing’s disease
hypothyroidism
familial
Prader-Willi syndrome
drugs
combined oral contraceptive pill
nicotinic acid
3
Q
pathophysiology
A
insulin resistance → hyperinsulinemia → stimulation of keratinocytes and dermal fibroblast proliferation via interaction with insulin-like growth factor receptor-1 (IGFR1)
