ACAAI/AAAAI lectures, T cell Biology Flashcards
Identify the following for Th1:
Induction cytokines STAT molecules involved Transcription factors involved Cytokines produced Function
Th1
Induction cytokines: IL-12, IFNg STAT: 4/1 Transcription factor: Tbet Produces: IFNg Function: Microbial immunity
Identify the following for Th2:
Induction cytokines STAT molecules involved Transcription factors involved Cytokines produced Function
Th2
Induction cytokines: IL-4 STAT molecules involved: STAT 6 Transcription factors involved: GATA3 Cytokines produced: IL-4, IL-5, IL-13 Function: Helminths
Identify the following for Th17:
Induction cytokines STAT molecules involved Transcription factors involved Cytokines produced Function
Th17:
Induction cytokines: IL-23, IL-1b STAT molecules involved: STAT 3 Transcription factors involved: RORgt Cytokines produced: IL-17, IL-21, IL-22, IL-26 Function: Fungi, mucosal integriy
Identify the following for TFH:
Induction cytokines STAT molecules involved Transcription factors involved Cytokines produced Function
TFH:
Induction cytokines: IL-6, IL-21 STAT molecules involved: STAT 3/4/1 Transcription factors involved: Bcl6, IRF-4 Cytokines produced: IL-21, IL-4, IL-10 Function: B cell help
Identify the following for TReg:
Induction cytokines STAT molecules involved Transcription factors involved Cytokines produced Function
TReg:
Induction cytokines: TGFb, IL-2 STAT molecules involved: STAT5 Transcription factors involved: FOXP3 Cytokines produced: TGFb, IL-10 Function: Homeostasis
What marker is expressed in central memory cells and not effector memory cells?
CCR7
What marker is characteristic of exhausted T cells?
PD-1
What happens to T effector memory cells and T central memory cells with age? What are the markers?
T effector memory cells (CD8+ T cells CD57+) increase with age
T central memory cells (CD8+ T cells CCR7+) decrease with age
What happens to naive and effector cells over time? What are the markers?
CD45+RA+ naive cells decrease over time
CD45+RO+ memory cells increase over time
What are the markers on pre-exhausted T effector memory cells (Temra)?
CD57+RA+
