Abx utilities Flashcards
Natural PCNs
Syphilis
Susceptible strep infxn (pharyngitis, endocarditis)
Antistaphylococcal PCNs
MSSA infxn (endocarditis, skin/soft tissue)
Aminopenicllins
Ampicillin DOC for for susceptible enterococci
Susceptible GNRs
URTIs (pharyngitis, otitis media)
Beta-lactam/Beta-lactamase Inhibitor Combinations
Zosyn/Timentin: Empiric therapy for nosocomial infxns
Augmentin: URTIs, LRTIs, UTIs
Mixed infxns d/t anaerobic activity (intra-abdominal, diabetic ulcers, aspiration pneumonia)
1st Generation Cephalosporins
Skin and soft tissue infxns
Surgical prophylaxis (cefazolin)
Staph bloodstream infxns
Endocarditis (MSSA)
2nd Generation Cephalosporins
URTIs
CAP
Gonorrhea
Surgical Prophylaxis (cefotetan, cefoxitin)
3rd Generation Cephalosporins
Lower respiratory tract infxns Pyelonephritis Nosocomial infxns (ceftazidime) Lyme disease (ceftriaxone) Meningitis Skin/soft tissue infxns Febrile neutropenia (ceftazidime) Gonorrhea (ceftriaxone DOC)
4th Generation Cephalosporins
Febrile neutropenia
Nosocomial infxns
Anti-MRSA Cephalosporin
FDA approved for only skin and soft tissue infxn and CAP
Cephalosporin/Beta-lactamase inhibitors
MDR pseudomonas infxns, mixed aerobic/anaerobic infxns, infxns caused by ESBL-producing organisms, intra-abdominal infxns
Ceftazidime/avibactam: carbapenem-resistant Enterobacteriacaea infxns
Carbapenems
Mixred aerobic/anaerobic infxns, infxns caused by ESBL-producing organisms, intra-abdominal infxns
Imipenem, doripenem, meropenem: nosocomial infxn, febrile neutropenia
Monobactams
G- infxns including pseudomonas, particularly in pts w/hx of beta-lactam allergy
Ciprofloxacin indications
UTI Intra-abdominal infxns Systemic G- infxns Pseudomonas infxns (+/- beta-lactam) Bioterrorism treatment/prophylaxis
Levofloxacin
CAP, sinusitis, bronchitis UTI intra-abdominal infxns Systemic G- infxns Skin/soft tissue infxns Pseudomonas infxns (+/- beta-lactam) Bioterrorism treatment/prophylaxis
Moxifloxacin
CAP, sinusitis, bronchitis
intra-abdominal infxns
Systemic G- infxns
Skin/soft tissue infxns