ABX that inhibit protein synthesis

Question 1

ABX that inhibit protein synthesis

Answer 1

Tetracyclines
macrolides
aminoglycosides

Question 2

tetracycline side effects

Answer 2

N, V, D, abd pain
liver toxicity
suprainfections
photosensitivity (sunburn type rxn)
teeth discoloration in children

Question 3

tetracycline interventions

Answer 3

monitor liver function
monitor for suprainfection
monitor for photosensitivity
determine if pt is pregnant
monitor and report GI s/s

Question 4

macrolides: Erythromycin
(other drug azithromycin [Zithromax])
side effects

Answer 4

N, V, D
suprainfection
ototoxicity, vertigo, tinnitus
Vent dysrhythmias

Question 5

macrolides: Erythromycin
(other drug azithromycin [Zithromax])
interventions

Answer 5

monitor for suprainfection
question about cardiac hx, monitor for dysrhythmias
monitor for ototoxicity
monitor drug serum levels

Question 6

aminoglycoside: gentramycin

side effects

Answer 6

ototxicity (when trough levels elevate above accepted levels)
headache and vertigo- first signs of ototoxicty
nephrotoxicity

Question 7

aminoglycoside: gentramycin

interventions

Answer 7

monitor for ototoxicity
monitor peak and trough levels
monitor lab values (BUN, creatinine, protouria