ABX-Table 1 Flashcards

1
Q

Traditional Pencillins

A

gram positive infections, block cell wall production, Streptococcus coverage

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2
Q

PCN tx

A

Syphilis

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3
Q

Traditional PCN are

A

PCN, Ampicillin, amoxicillin

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4
Q

Traditional pcn tx?

A

GBS prophylaxis in pregnant women(prevent meningitis)

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5
Q

Amoxicillin covers?

A

Ear infections(children), strep throat- STREP infections

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6
Q

Semi synthetic PCNs?

A

Oxacillin, Nafcillin, Dicloxacillin, Cloxacillin-

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7
Q

What do semi-synthetic pcns tx?

A

STAPH- NOT MRSA

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8
Q

Ampicllin tx?

A

Lyme disease

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9
Q

What are the generations of cephalosporins representing?

A

1-4 generations, first and second are good for

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10
Q

What do cephalosporins not cover?

A

Listeria and MRSA

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11
Q

What do cephalosporins cover?

A

Ceftazidime and cefepime cover pseudomonas

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12
Q

What percent cross sensitivity can be observed from ppl with a pcn allergy, when initiating a cephalosporin?

A

3-5%

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13
Q

What is the 4th gen cephalosporin?

A

Cefepime

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14
Q

What are the macrolides?

A

Erythromycin, azithromycin, clarithromycin

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15
Q

What do you use when a pt has strep throat, but us allergic to PCN?

A

Macrolide!

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16
Q

What do macrolides cover that is different from PCNs?

A

additionally covers atypicals! (ligionella, mycoplasma, mycobacteria, chlamydia, H influenzae)

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17
Q

What macrolide is the drug of choice for walking pneumonia?

A

Azithromycin

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18
Q

What else does azithromycin tx, usually with ceftriaxone?

A

tx. of chlymydia and gonorrhea

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19
Q

What do Quinolones cover?

A

Broad spectrum, covers gram positive staph and strep AND gram negative AND atypicals! good empiric therapy for pneumonia

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20
Q

What are the quinolones?

A

Levofloxacin, ciprofloxacin, gatifloxacin, moxifloxacin, quinupristin

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21
Q

What are the risks of perscribing a quinolone?

A

tendon rupture, C.diff, don’t use in pregnancy, DNA gyrase formation inhibited

22
Q

Are quinolones used in UTI and prostatitis tx?

A

YES!, and intractible infectious diarrhea

23
Q

Aminoglycosides are?

A

Gentamycin, tobramycin, amikacin

24
Q

What do aminoglycosides cover?

A

Pseudomonas, listeria, and gram negatives

25
Q

AEDs of aminoglycosides?

A

ototoxicity, renal toxic, never used in pregnant women

26
Q

What is amp/gentamicin used to tx?

A

severe internal infection like endocarditis or listeris meningitis

27
Q

CF aminoglycoside used?

A

nebulized tobramycin d/t pseudomonas colinization.

28
Q

what are the Carbapenems

A

Imipenem, meropenem, ertapenem,

29
Q

What do cabapenems cover?

A

Positive, negative and anaerobics,

30
Q

what are cabapenems not effective against?

A

Atypicals

31
Q

which carbapenems are effective agains pseudomonas?

A

Imipenem, miropenem

32
Q

When are carbapenems used as DOC?

A

during febrile neurtropenia of unknown origin

33
Q

what are the tetracyclines?

A

Doxycycline, tetracycline, tigecycline

34
Q

what do tetracyclines used for?

A

Doxi against rickettsia, malaria prevention,

35
Q

Tigacycline covers what?

A

MRSA!!- usually in skin and soft tissue and intra abdominal infections

36
Q

What are the ADRs of tetracyclines?

A

don’t use in children or pregnant women- stains teeth in child

37
Q

What does vancomycin cover?

A

Gram postiive and anaerobes, C.diff and MRSA

38
Q

what is vancomycin primarily cover?

A

C.diff(IV)and MRSA

39
Q

What is the DOC for C.diff?

A

Vancomycin

40
Q

What PCN/beta lactamase combo used for pseudomonas?

A

Pipercillin/tazobactam

41
Q

What is augmentin?

A

Amoxicillin/clavulanate

42
Q

What is Zosyn?

A

pipercillin/tazobactam

43
Q

What drugs cover anaerobes?

A

Clindamycin and metronidazole

44
Q

What is used for anaerobes below the diaphram?

A

Metronidazole

45
Q

What is used for anaerobes above the diaphragm?

A

Clindamycin

46
Q

what are the adrs of clindamycin?

A

Cdiff!! big time!

47
Q

what is most commonly used for utis?

A

Trimethoprim/sulfamethozasole- not in pregnancy though

48
Q

what is rifampicin used for?

A

TB tx, prophylaxis of meningococcal meningitis and H.influ infections

49
Q

What is linezolid used for?

A

highly resistant skin infections with MRSA

50
Q

what is quinupristin/dalfopristin used for?

A

treat MRSA!!

51
Q

What drugs treat pseudomonas?

A

pipercillin/tazobactam, ceftazidime, defipime, imipenem, meropenem, gentamicin, amikacin, tobramycin, aztreonam

52
Q

what tx mrsa

A

vanco, linesolid, tigacycline, quinupristin/dalfopristin