ABX Flashcards
Fluoroquinolones
Ciprofloxacin
Levofloxacin
Moxifloxacin
MOA of Fluoroquinolones
Bacterialcidal
inhibit DNA gyrase enzyme, inhibiting DNA synthesis
Macrolides
Azithromycin
Clarithromycin
Erythromcycin
MOA Macrolides
Protein Synthesis inhibition via anti 30S subunit
-Bacterostatic
Tetracyclines
Tetracycline
Doxycycline
Minocycline
*Spirochetes
Aminoglycosides
Gentamicin
Neomycin
Tobramycin
MOA Aminoglycosides
Protein Synthesis inhibition via anti 30S subunit
-Bacterocidal
Beta-lactamase inhibitors
Clavulanic Acid
Sulbactam
Tazobactam
MOA of Beta-lactamase inhibitors
- Cell Wall inhibitor
- Bactericidal - blocks cross linking
Cephalosporins 1st 2nd 3rd 4th
1st- Cefazolin (Ancef), Cephalexin (Keflex)
2nd- Cefoxitin, cefuroximine
3rd- Ceftriaxone (Rocephin), Ceftazidime, 4th- Cefepime
MOA of Cephalosporins
- Bactericidal
- inhibit bacterial cell wall synthesis
PCN’s
Penicillin G Amoxicillin Ampicillin Oxacillin Dicloxacillin Piperacillin
MOA of PCN’s
Bactericidal
-block cross linking, inhibiting cell wall synthesis
Carbapenems
Imipenem
Meropenem
(Broadest activity - no activity against MRSA)
Gram + Cocci
Staph aureus
Strep epidermis
Strep pneumo