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Biochem 4LE HM > Absorption and transport > Flashcards

Absorption and transport Flashcards

1
Q

Initial development of cell-cell contacts via E-cadheren bond rather than paracellular transport

Tight Junction
Adherens Junction

A

Adherens Junction

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2
Q

Direct relationship between the number of proteins strands and the permeability of the epithelial cells

Tight Junction
Adherens Junction

A

Tight Junction

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3
Q

Have high levels of E-cadherens

Tight Junction
Adherens Junction

A

Adherens Junction

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4
Q

dictates the size of pores and ionic permeability of paracellular pores

Claudins
Occludens
Junctional Adherent Molecules (JAMS)

A

Claudins

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5
Q

No paracellular transport function

Claudins
Occludens
Junctional Adherent Molecules (JAMS)

A

Occludens

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6
Q

single membrane spanning polypeptide, regulates the sealing and permeability of TJ

Claudins
Occludens
Junctional Adherent Molecules (JAMS)

A

Junctional Adherent Molecules (JAMS)

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7
Q

TJ overall effect

increase permeability of TJ ->

inc fluid loss
dec fluid loss

A

inc fluid loss

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8
Q

opens and closes TJ

A

zono occludens

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9
Q

involves a transporter and ATP hydrolysis

primary transport
secondary transport

A

primary transport

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10
Q

benifits electrochemical gradient bought by ATP hydrolysis

primary transport
secondary transport

A

secondary transport

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11
Q

TJ secretes__ to increase barrier function

Na
Cl
K
HCO3

A

Cl

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12
Q

Intestinal fluid movement is predominatly controlled by active trasnport of

Na
Cl
K
HCO3

A

Na
Cl
K
HCO3

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13
Q

Different expression of specific transporters at apical and basolateral poles of enterocytes (Apical Pole or Basolaterla POle)

Na-K ATPase
Na Channel
Cl channels
SGLT1

A

Na-K ATPase - Baso
Na Channel - Apical
Cl channels - baso
SGLT1 - apical

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14
Q

Basolateral, Apical, Bilateral?

  • receptors for luminal regulatory factors
  • receptors for kinins
  • presence of lymphatics and blood circulation for easy coupling
  • receptors for adenosine
A
  • apical
  • bilateral
  • baso;lateral
  • bilateral
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15
Q

They are recruited for development of functional polarity

A

catenins

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16
Q

Spatial location : Transport porteins

Villus surface: ____

Na channels
Na nutrient
Na pumps
SGLT1
NHE1
NHE2
NHE3
CFTR
DRA
PAT 1
A 
Na channels
Na nutrient
SGLT1
NHE2
NHE3
PAT 1
17
Q

Spatial location : Transport porteins

crypts : ___

Na channels
Na nutrient
Na pumps
SGLT1
NHE1
NHE2
NHE3
CFTR
DRA
PAT 1
A

CFTR

18
Q

Spatial location : Transport porteins

Regular distribution: _

Na channels
Na nutrient
Na pumps
SGLT1
NHE1
NHE2
NHE3
CFTR
DRA
PAT 1
A

DRA
Na pumps
NHE1

19
Q

Enterocytes, goblet cells, paneth cells, enteroendocrine, stem cells

a. ) sense changes in luminal environment and adjust correspondingly
b) most common type with absorptive and secretory function
c) mucus secretion
d. )found in the crypts and can develop in to the other four types
e) defense by secretion of anti-bacterial peptides

A

a. enteroendocrine
b. Enterocytes
c. goblet cells
d. stem cells
e. paneth cells

20
Q

(inc/dec????) Na+/nutrient-coupled transport opening of TJ - ↑ fluid absorption via TJ

↑ Cl- secretion - (inc /dec????) barrier function

A

inc

inc

21
Q

Type of electrogenic transport or eletroneutral transport

  • Na/H exchanger
  • Na/glucoes transporter
  • Na/K/2Cl cotranspoter
A

eletroneutral
electrogenic
eletroneutral

22
Q

Transcellular transport, pump usually use ___ bexause pumps needs to be phophorlated during transport

A

ATP

23
Q

ATPase pumps heterodimers (alpha and beta subunits) inhibited by ___

A

Quabain

24
Q

ATPase pumps heterodimers (alpha and beta subunits?)

  • correct assembly and membrane targeting
  • contains the ion binding, catalytic and inhibitor sites
A

beat

alpha

25
Q

water selective channelsfor absorption of water

A

aquaporins

26
Q

basolateral proteins in small intestines and colon

AQP3
AQP4
AQP8

A

AQP4

27
Q

surface / villi of jejunums and colon

AQP3
AQP4
AQP8

A

AQP8

28
Q

surface / villi of jejunum, ileum and colon

AQP3
AQP4
AQP8

A

AQP3

29
Q

aquaporins found in surface / villi of jejunums

AQP3
AQP4
AQP8

A

AQP3

AQP8

30
Q

aquaporin in colon

AQP3
AQP4
AQP8

A

AQP3
AQP4
AQP8

Biochem 4LE HM (3 decks)

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