ABs in autoimmune diseases

Question 1

Anticentromere

Answer 1

Limited scleroderma (CREST syndrome)

Question 2

Anti-Desmosome (anti-desmoglein)

Answer 2

Pemphigus Vulgaris

Question 3

Anti-glutamic acid decarboxylase (GAD-65)

Answer 3

type 1 diabetes mellitus

Question 4

Antihemidesmosome

Answer 4

Bullous pempigoid

Question 5

Anti-histone

Answer 5

Drug induced lupus

Question 6

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 6

Polymyositis, dermatomyositis

Question 7

Antimicrosomal, antithyroglobulin

Answer 7

Hashimoto thyroiditis

Question 8

Antimitochondrial

Answer 8

1o biliary cirrhosis

Question 9

Anti-Scl-70 (anti-DNA topoisonmerase I)

Answer 9

Scleroderma (diffuse)

Question 10

Anti-smooth muscle

Answer 10

Autoimmune hepatitis

Question 11

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 11

Sjogren Syndrome

Question 12

Anti-U1 RNP (ribonucleoprotein)

Answer 12

mixed connective tissue disease

Question 13

IgA anti-endomysial, IgA anti-tissue transglutaminase

Answer 13

celiac disease

Question 14

MPO-ANCA/p-ANCA

Answer 14

microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (churg-strauss syndrome)

Question 15

PR3-ANCA/c-ANCA

Answer 15

granulomatosis with polyangiitis (Wegener)

Question 16

Rheumatoid factor (IgM AB that targets IgG Fc region), anti-CCP (more specific)

Answer 16

Rheumatoid arthritis