abnormal bleeding Flashcards
Menorrhagia
hypermenorrhea): prolonged duration of menses (>7 days) and/or increased amount of bleeding (>80mL) occurring at regular intervals
Hypomenorrhea:
unusually scanty menstrual bleeding lasting for less than 2 days; menses occur at regular intervals
Metrorrhagia:
uterine bleeding at irregular intervals, particularly between expected menstrual periods
Bleeding between periods
Menometrorrhagia
uterine bleeding that is prolonged and completely irregular
Polymenorrhea
frequent but regular menstrual cycles (<21 days
Oligomenorhea:
regular but prolonged menstrual cycles (>35 days)
Amenorrhea:
no menstrual bleeding for at least 3 cycles or 6 months
Postmenopausal bleeding (PMB):
uterine bleeding that occurs more than 12 months after the last menstrual period
Postcoital bleeding
vaginal bleeding during or after intercourse
Dysmenorrhea
painful menses
Anovulatory bleeding:
uterine bleeding that is not associated with ovulation
Dysfunctional uterine bleeding (DUB):
abnormal uterine bleeding with no demonstrable organic cause; a diagnosis of exclusion
- Normal menses should be about every
every 21-35 days
– Variability in more than______ is considered irregular
- Variability in more than 20 days is considered irregular
VulvoVaginal causes of bleeding
Trauma Cancer Atrophy Infection Benign growths
Ectropion can cause what kind of bleeding
causes post coital bleeding
Polyps can cause what kid of bleeding
causes post coital bleeding
causes of uterine bleeding
DUB Leiomyoma; structural abnormalities ectopic ovulatory dysfunction bleeding disorder infection endometrial cancer
ovarian or adnexal causes of bleeding
salpingitis PID ovarian cancer (VERY UNUSUAL)
structural causes
i. Polyp, Adenomyosis, Leiomyoma, Malignancy & hyperplasia
bleeding in post menopause
uterine ca
neonates vaginal bleeding
estrogen w/d 30 days
precocious puberty
early as 8
post menopausal causes of bleeding
HRT
endometrial CA
atrophy (5 or 6 years post menopause)
PALM COING
non gravid reproductive
age causes of bleeding
polyp
adenomyosis
leiomyoma
malignancy and hyperplasia
unrelated to structure
coagulopathy ovulatory dysfunction endometrial iatrogenic not yet classified
liver or renal disease
can cause these problems as well
cervical cytology results that would indicate the need for EMB
AGC of the endometrium (high risk)
ACG of all other categories if >35 or have other risk factos’
bleeding in women >40
Associated molimenol sx in a pt with irregular bleeding you would think
(breast tenderness, cramping, moody, etc) –
suggest ovulatory cause
quantitative pregnancy
test
allows you to see what is happening over time via hcg
45 yo G3P3 female c/o heavy, prolonged menstrual bleeding x 4-6 mos. BTL 5 yrs ago. No meds, NKDA. She is using 8-10 tampons/day for 5-7 days and her cycles are 21-25 days in length. This is increased from baseline of 3-4 tampons/day for 3-5 days and 28-30 day cycles for 20+ years. All pregnancies uncomplicated. No PMH; FH noncontributory.
DDX
perimenopause
Polyps
Adenomyosis
Leiyoma
Malignancy
Coagulopathy Ovulatory dysfunction Enodemtium Iantrogenic Not yet classified
hypothyroidism
adenomyosis
Islands ofendometrial tissue within the myometrium (muscular layer of the uterine wall).
sxs of adenomyosis
Menorrhagia (progressively worsens), dysmenorrhea, infertility.
symmetric
soft
tender
physical exam with adenomyosis
(uniformly)enlarged”boggyuterus”*
“globular” enlargement.
adenomyosis vs endometriosis
endometriosis is outside of the uterus
adenomyosis is in the uterine wall
endometritis
post partum
fever
vaginal discharge
PID more typical in younger women
endometrial polyp is associated with
mertorrhagia
non tender mobile uterus
most likely benign fibroids
when do you send pts to the ER for anemia
hgb <10
or sxs
can also send pt to blood bank
MC pelvic tumor and MCC of hevay vaginal bleeding
leyomyomas
myomas or fibroids
made from smooth muscle cells
DUB dx by
ovulatory or anovulatory
tx of acute bleed
usually avoid medoxyprogesterone (Provera)
micornized progestrone is safer but you can use either
Provera (MPA)20 mg PO QD x10 days or Prometrium 200 mg x 14 days
both of these organize the endometrium
Moderate bleeding >3 days:
monophasic oral contraceptive BID-TID x 5-7 days
extreme bleeding DUB tx
inpatient
Conjugated Estrogen (Premarin) 25 mg IV Q6H x 4 doses, then progesterone or surgical curettage
reoccurent DUB tx
OCP one tablet per day for 21 days
better to use IUD
OR intermitten progesterone therapy
Medroxyprogesterone acetate 10mg daily, Day1-10 of each month/cycle
Most common cause of DUB in adolescents
Anovulatory Cycles
Responses to anovulation
amenorrhea
estrogen withdrawal bleeding
estrogen breakthrough bleeding: stromal crowding
heavy (menorrhagia) or irregular (metrorrhagia) bleeding
tx of DUB in immature HPO axis
Progestin therapy 10 days every month or every other until full maturity of the axis provides effective therapy
Low dose OCP’s
Progestin therapy does not interfere with the normal progression to spontaneous ovulatory cycles.
Perimenopausal Women DUB needed
Endometrial biopsy (EMB) Endovaginal ultrasound (endometrial stripe < 5mm) Saline ultrasound (SIS)
TX of DUB in perimeno woman
Atrophic vaginitis: Topical estrogen
Endometrial atrophy: due to hypoestrogenism resulting in thinning of surface that is prone to bleeding
Endometrial hyperplasia: continuous bleeding
Progesterone x 3-6 months, then re-biopsy
Tri-cyclic or continuous HRT
post coital bleed DDX
Endocervical infection (GC,Chlamydia) Cervical or vaginal warts Friable ectropion Neoplasia (invasive): Vaginal, cervical, endocervical, or endometrial Endometritis (acute or chronic) Polyp: Endocervical or endometrial Vaginal foreign body Urethral lesion
endometrial ablation requires
Requires normal EMB
and negative pregnancy test
Not effective if submucosal fibroids