AB L2.2 Helminth treatment Flashcards
Treatment for filarial nematode
Ivermectin
How does ivermectin work?
Blocks ion channels - paralysis
Treatment for intestinal nematodes
Albendazole/mebendazole
How does albendazole/mebendazole work?
Blocks microtubulin assembly and inhibits glucose uptake
Treatment for tapeworms
Niclosamide
How does niclosamide work?
Uncouples oxidative phosphorylation
Is there resistance to most of these drugs?
No
Does treatment usually work?
Yes - usually only single dose needed
Treatment for roundworms and treadoworms
Piperazine
How does piperazine work
Blocks neurotransmitter - paralysis
What do we usually give with piperazine?
Laxatives (sennosides)
Treatment for flukes and tapeworms?
Praziquantel
How does praziquantel work?
Alters Ca - paralysis
Helminths are potential therapeutics because?
they are able to modulate the immune system
Helminths have investigated as therapeutics in (2)
Allergy and asthma
There is an inverse correlation between incidence of …….. and hookworm infection
asthma
Treatment seems easy so what is the problem?
People get reinfected - now the focus is more reducing the number of worms around (fewer worms in person, safer disease)
Elaphatisis is caused by….
Filarial nematodes
What malaria treatment is suitable for a healthy adult travelling to sub saharan africa?
Atovaquone-proguanil
Schistosomes usually enter the body through….
infective larvae that penetrate the skin of their host
Intestinal helminth infections are usually diagnosed by…
eggs in feces
