AA metabolism, Urea Cycle Flashcards
What is the alpha keto cousin of aspartate?
oxaloacetate
What is the alpha keto cousin of alanine?
pyruvate
What is the alpha keto cousin of glutamate and glutamine?
alpha ketoglutarate
_____ and ____ are used to transport NH3 groups between tissues
glutamine and alanine
What is the function of glutamine synthetase?
It synthesizes glutamine from glutamate. It uses NH3 and ATP.
What is the function of carbamoyl-phosphate synthetase-I?
adds 2 ATP, bicarbonate, and free ammonia to produce carbamoyl-phosphate
What is the function of glycine synthase?
It produces glycine from N5. N10-methyl THF
What is the function of glutamate dehydrogenase?
Converts glutamate to alpha ketoglutarate
What is the function of glutaminase?
Converts glutamine to glutamate
In the liver, glutaminase generates ___ for secretion
NH3