9.9 Osmoregulation Flashcards
How many kidneys do we have?
Two
Where are the kidneys found?
Rear of the abdomen
Either side of the aorta
Explain the structure of a kidney
Outer layer is the cortex Inner is medulla Inside medulla is the pelvis Ureter leading off Renal artery and vein
What is the main function of the structures in the cortex?
Filtering toxins such as urea
What is the main function of the structures in the medulla?
Osmoregulation - regulating water potential
What is osmoregulation?
The regulation of the water potential of the body within narrow limits by controlling the concentration of water and salt
What are the main organs involved in osmoregulation?
Kidneys and liver
Where are amino acids deaminated?
In the liver
Explain how amino acids are deaminated?
Amino group removed
Converted to ammonia
Converted to urea
Why does ammonia need to be converted to urea?
Urea is non-toxic, ammonia is toxic
What are the two main functions of the kidney?
Waste filtration
Osmoregulation
What is the function of the ureter?
Carrying urine to the bladder
Where does ultrafiltration take place?
Glomerulus
in the cortex
What are the three layers which the filtrate goes through during ultrafiltration?
Endothelium
Basement membranes
Podocytes
Explain the process of ultrafiltration
High blood pressure in glomerulus
Forces blood through three stage filtration mechanism:
Fenestrations in the endothelium –> basement membrane –> gaps in the podocytes
Proteins and blood cells can’t pass through bc too big
What causes the high blood pressure in the glomerulus?
Afferent arteriole is wider than the efferent arteriole
What substances are found in the glomerular filtrate?
Glucose
Urea
Water
Where does selective reabsorption take place?
Proximal convoluted tubule
Where does the filtrate from the glomerulus go?
To the Bowman’s capsule
Name some of the adaptations of the PCT?
Brush border of microvilli - increases surface area for reabsorption
Mitochondria - ATP for active transport
PCT is one cell thick - short diffusion distance
Close to capillaries - conc gradient and short diffusion distance
Explain the process of selective reabsorption in the PCT
Na+ actively pumped out of PCT wall into the blood using ATP
Na+ and glucose co-transported into the PCT wall from PCT lumen by facilitated diffusion down conc gradient with protein carrier
Na+ and glucose levels build up - move into blood by diffusion
Increases water potential of the PCT wall - water leaves
What is reabsorbed by the body during selective reabsorption?
All of the glucose and amino acids
Some water
Explain how the loop of Henle works
Ascending and descending limb
Asc. impermeable to water
Na+ and Cl- actively removed from ascending
Lowers water potential in the medullary region
Longer loop of Henle - lower water potential
Water moves out of descending limb by osmosis
Some Na+ diffuses into descending limb
Vasa recta acts as a counter current multiplier