91 - Stomach Flashcards

1
Q

Describe the arterial vascular supply to the stomach

A

Aorta => Celiac => Splenic/Left gastric/Hepatic

  • Splenic => Left gastroepiploic (greater curvature) & Short gastrics (fundus)
  • Left gastric => Lesser curvature, fundus and terminal oesophagus
  • Hepatic => Right gastric (lesser curvature) and gastroduodenal => Right gastroepiploic (greater curvature)

Right and left gastric anastomose on lesser curvature
Rihgt and left gastroepiploic anasomoase on greater curvature

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2
Q

Describe the venous drainage of the stomach

A

SPLENIC VEIN ON THE LEFT
(Left gastric v joins splenic)

GASTRODUODENAL VEIN ON THE RIGHT
(Right gastric v joins gastroduodenal)

DRAIN INTO THE PORTAL VEIN

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3
Q

Describe the innervation to the stomach

A

Parasympathetic = Vagus n.
- Dorsal and ventral trunks

Sympathetic = Celiacomesenteric plexus

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4
Q

Which LNs does the stomach drain to?

A

Gastric and Splenic LNs

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5
Q

Label the diagram

A

A = Fundus
B= Body
C= Pyloric antrum
D = Pyloric canal
E = Angular incisure
F = Major duodenal papilla
G = Minor duodenal papilla

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6
Q

How is the muscularis of the stomach organised?

A

3 layers
- Longitudinal fibres from oesophagus to duodenum
- Inner circular fibres from the cardia (cardiac sphincter) extendong to greater curvature
- Inner oblique fibres (blend with circular layers) from greater curvature to pylorus = grinding function of the antrum

Circular layer not present at the fundus

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7
Q

Describe the anatomy of the omentum

A

Greater and lesser omentum attach to respective curvatures

Greater split into =
- Bursal (Greater curvature but courses obliquely to join with lesser to create bursa)
- Splenic (Fors gastrosplenic ligament containing left gastroepiploic vessels)
- **Veil ** (between descending mesocolon and spleen)

Portion of lesser forms hepatogastric ligament

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8
Q

What is the clinical relevence of the angular incisure?

A

Useful landmark for endoscopy

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9
Q

What are the 3 layers of the gastric mucosa?

A

Columnar epithelium
Glandualar lamina propria
Lamina muscularis

(Mucosa, Submucosa, Muscularis, Serosa as for elswehere in GIT)
Submucosa = Strength holding layer

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10
Q

What are the gland types within the stomach?

What do they each secrete?

A

Cardiac = Serous secretions

Pyloric = Mucous secretions

Gastric glands proper = Reside in the body
- Parietal cells => 1) Intrinsic factor and 2) Hydogen ions to reduce pH
- Chief cells => Pepsinogen (converted to pepsin to digest proteins)
- Mucous neck cells => Mucin (protect against low pH)
- Endocrine cells => Seratonin, histamine and gastrin production

Intrinsic factor, mucus and bicarb protect cells from acidic pH

Remember parietal = pH
Chiefs tend to be hench = Pepsinogen > Pepsin > Digests proteins

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11
Q

Describe the the main phases involved in gastric motility

A

1) Fundic distension
* Swallowing initiates receptive relaxation of the fundus
* Decrease in motor activity and pressure
* Gastric accomodation occurs which decreases rate of emptying of fluids

2) Gastric distension
* Distension of the stomach causes increase in motility
* Food is mixed and moved towards the antrum for churning

3) Contractile retropulsion
* Pylorus closes
* Liquid moves into the duodenum
* Particles > 2mm in size are forced retrograde for further churning
* Particle size reduced to 0.1-0.6mm for gastric emptying

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12
Q

How does the stomach heal depending on the thickness of the lesion?

A

Partial thickness mucosa = Epithelialisation

Extending to submucosa (ULCER) = Fibrosis

Incisional = Inflammation, debridement, repair, maturation
(Smooth muscle in the stomach contributes to collagen production during healing)

There is constant mucosal renewal in the stomach

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13
Q

Considerations for pre-op fasting for gastric surgery?

A

8-12 hour fast reduces spillage
- But reduces pH and increases occurence of reflux

Feeding small meal of tinned food 3 hours prior to surgery
- Increases pH and reduces the impact of reflux

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14
Q

When are perioperative antibiotics indicated for gastric surgery?

A

Generally, low bacterial numbers due to low pH

GI Obstruction => Bacterial overgrowth so consider periop ABs for this

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15
Q

Name 3 GA concerns for gastric surgery and give solutions

A

1) Reflux
- Anticholinergics (glyco/atropine) to reduce secretions
- H2 receptor antagonist and PPIs to increase pH

2) Vomiting
- Rapid induction (propofol) and intubation
- Antiemetics?

3) Abdominal distension
- Mechanical ventilation

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16
Q

Describe the paracostal approach to the stomach

A

Incision 2cm caudal to last rib
Skin, subcut, EAO, IAO, TA, peritoneum
Muscles split in direction of fibres

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17
Q

What temperature is appropriate for abdominal lavage?

What is the risk of using warmer fluids?

A

37-39°

Risks of warmer
- Vasodilation
- Hypotension
- Increased adhesions (41-45°)

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18
Q

What suture patterns does Tobias recommend for closure of the stomach?

A

Double layer continuous with inversion

Either double inversion
- First full thickness
- Second seromuscular

Or
-Mucosal/submucosal apposition
Seromuscular inversion

First layer = Haemostasis
Second layer = Creates seal

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19
Q

Where should invertion NOT be performed and why ?

A

Pylorus

Inversion reduces luminal size

Interrupted or continous appositional recommended for pyloroplasty

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20
Q

Which suture material is negatively impacted by low pH?

A

PDS

But in clinical situation, generally fine

Half life PDS 12 days vs 75 days for Maxon vs 15 days for monocryl

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21
Q

Name 3 tests for assessment of gastric viability

A
  • Fluorosceine dye injection (58% accurate)
  • Scintigraphy (79% accurate)
  • Laser Doppler Flowmetry
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22
Q

How accurate are subjective assessments of gastric viability in experience surgeons hands?

A

85%

Standard subjective measures - Thickness, colour, serosal capillary perfusion, peristalsis

Remember mucosa viability does not equate to overall viability

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23
Q

Briefly described a hand sewn partial gastrectomy

A

Resect affected tissue and margin of normal tissue with Metz so actively bleeding
Close defect with 2/0-3/0 Monofilament absorbable
Close Perpendicular or parallel to the long axis depending on defect shape
Two layer closure
Omentalisation

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24
Q

Other than hand sewn, name 3 other options for partial gastrectomy

A

Stapling device
* TA/GIA, plus oversew

Gastric wall invagination
* Simple continous and inverting second layer
* Necrotic region sloughs into lumen

Autologous intestinal submucosal graft
* Useful when resection results in inadequate functional lumenal diameter

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25
Q

Name 4 complications of gastric wall invagination

A
  • Gastric ulceration
  • Gastric wall abscess
  • Obstruction due to sloughing material
  • Haemorrhage secondary to deep ulceration
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26
Q

Name 12 techniques for gastropexy

A

Open =
* Incisional
* Belt loop
* Circumcostal
* Incorperating
* Gastrocolopexy
* (Stapled gastropexy)
* (Tube gastropexy via gastrostomy)

Minimally invasive =
* Grid approach
* Endoscopically assisted
* Laparoscopic assisted
* Laparoscopic gastropexy
* (Percutaenous endoscopic gastostomy - PEG tube)

In brackets, not in tobias or mentioned elsewhere

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27
Q

How long should the incision be for incisional gastropexy

At what location should the incisions be made?

In which layers should the incision be made?

A

4-5cm long

Pyloric antrum and 2-3 caudal to last rib

Seromuscular layer and through peritoneum and transverse abdominis

Simple continous, 2/0 monofilament
Start at craniodorsal aspect of incision

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28
Q

Where should the flap be created from for belt loop gastropexy and flap dimensions?

What should be included in the flap?

How long should the incisions in the transverse abdominis be?

A

Seromuscular flap in the pyloric antrum
- 4 cm long, 3cm wide, base at the greater curvature
- Gastriepiploic branches included

Incision in TA
- 5cm long, 3 cm apart
- Muscle undermined to create tunnel

Use stay suture to pass flap through tunnel
Suture back to site with 2/0-3/0 monofilament

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29
Q

At what location should the flap be passed around the rib during circumcostal gastropexy?

A

Chostochondral junction of the 11-12th rib

5-6cm incision made over the rib and blunt dissection performed circumfrentially

Flap otherwise as for belt loop
Can be single or double hinged

Avoid pneumothorax and rib fracture

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30
Q

How is gastrocolopexy performed?

A

Suture between greater curvature and transverse colon
No incision in seromuscular layers
Surfaces scarified and apposed with non-absorbable suture

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31
Q

Describe the incorperating gastopexy

What is the specific risk of this technique?

A

Pyloric antrum incorperated into CRANIAL linea alba during closure. No seromuscular incision. Quick!

Risk = inadvertant penetraiton of stomach during future abdominal surgery

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32
Q

Briefly describe the grid approach for gastropexy

A
  • 6cm long incision - Caudal and ventral to 13th rib
  • Skin, SC, EAO, IAO, TA, peritoneum
  • Pyloric antrum grabbed with Babcocks
  • Stays placed to mobilise into surgical site
  • 3cm longitudinal incision through seromusclar layer
  • Edges of gastric incision sutures to edges of TA fascia and muscle
  • Superficial layers reapposed
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33
Q

Describe the technique for endoscopically assisted gastropexy

A
  • Left oblique recumbency
  • Gastroscope passed and stomach insufflated
  • Antrum assessed and right abdominal wall palpated
  • 2 Prolene on 76 mm needle
  • Stay suture passed through body wall, caudal to13th rib, into stomach lumen and out through body wall
  • Minimum 2cm gastric tissue incorperated
  • Second suture placed 5cm aboral to first under in same way
  • Incision made in body wall between sutures
  • Gastric seromuscular layer incised and edges sutured to TA
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34
Q

What is the difference between lap assisted and laparoscopic gastropexy?

A

Lap assisted
- Subumbilical port and Working port lateral to margin of right rectus 3cm caudal to last run under direct visualisation
- Pyloric antrum grasped with Lap babocks and positioned adjacent to wall
- Foceps and cannula withdrawn to exteriorise antrum
- Port incision extended to 4cm
- Stay sutures placed to secure antrum
- Seromuscular incision made and sutured as for grid approach

Laparoscopic gastropexy
- 3 portals on ventral midline (subumbilicus, 3cm caudal to xiphoid and midway between the two - medial to gastropexy site)
- Camera in middle portal
- TA and seromuscular incision made with laparoscopic Metz
- Sutures with suture assist and lap needle holders, intracorporeal hand suturing, Barbed suture or stapled gastropexy

35
Q

Describe the
Fredet-Ramstedt Pyloromyotomy

A

Longitidinal seromuscular incision
Ventral pylorus
Extending 1-2cm orad and aborad

Can be performed laparoscopically

36
Q

Describe the
Heineke-Mikulicz Pyloroplasty

A

Full thickness LONGITUDINAL incision made in the same location as the Fredet-Ramstedt
Stay sutures placed to reorientate incision
CLOSED TRANSVERSELY
Appositional interrupted closure

37
Q

What is the aim of a Y-U pyloroplasty?

How does it achieve this?

A

Increasing diameter of the pyloric outflow tract

Advancing the pyloric antrum into the region of the pyloric sphincter

38
Q

Describe the technique for Y-U pyloroplasty

A

Full thickness Y shaped incision
- Stem = Ventral antemesenteric duodenum
- Arms = Pyloric atrum
- Should curve into a U shape (rather than a V) to maximise vascular supply

Full thickness biopsy of the margin of the pyloric incision

Mucosa and submucosa resected as needed

U shaped flap advanced using stays
Sutured using 2/0 Absorbable monofilament
Appositional (interrupted or continous)

Assess patency of pylorus after closure

Place J-G tube to avoid feeding into stomach?

Regurge post op common - pylorus has impact on motility

39
Q

What is involved in a Bilroth I?

When is it indicated?

Which structures make anatomy challenging?

A

Bilroth I = Gastroduodenal anastomosis

Indications =
- Pyloric hypertrophy
- Ulceration
- Neoplasia

Anatomical challenges
- Bile duct
- Pancreatic ducts
- Vascular supply

40
Q

Describe the bilroth 1 approach

A

Stays placed in somach and duodenum
Atraumatic clamps placed
Hepatogastric ligament transected, avoiding the bule duct
Leave 5-10mm between resection site and major duodenal papilla bile duct
Ligate ant transect right gastric and right gastroepiploic branches
Divide omental and mesenteric attachments
Remove pylorus with Metz or blade
Assess luminal disparity
Spatulate antemesenteric duodenum if needed or close pyloric antrum to itself to narrow diameter
Single or double layer end to end or EEA stapler
Stent common bile duct if neededd

41
Q

What are the main complications following bilroth I

A

Hyperbilirubinaemia
Anaemia

42
Q

What is a Bilroth II?

A

Gastrojejunal anastomosis
(Side to side anastomosis)
Cholecystoenerostomy required for biliary flow

Poor prognosis not recommended

43
Q

What is the diagnosis?

A

Type I Hiatal hernia

Apple coring appearance around GEJ within the thorax

44
Q

Define Hiatal hernia

What are the 4 types?

Name one additional class of hiatal hernia

A

Herniation of abdominal contents through the oesophageal hiatus

Type I = Sliding hiatal hernia
- GEJ intermittently moves into the thorax

Type II = Paraoesophageal
- GEJ remains within the abdomen but the fundus moves into the thorax

Type III = Elements of II and III
- GEJ and fundus move into the thorax

Type IV = Herniation of other organs into thorax

GASTROESOPHAGEAL INTUSUSCEPTION =
- Stomach invaginates orad to into the oesophagus

45
Q

Which breeds are over-represented for Congenital type I Hiatal hernia?

A

Sharpei

English Bulldog

2-4 months (time of weaning)
May not be clinical unless aspirated

46
Q

How is oesophagoscopy useful in the assessment of hiatal hernias?

A

Assesss for secondary oesophagitis

Herniation can be induced by temporary occlusion of the ETT (inducing negative pressure)

Positive contrast Fluoroscopy useful for Type I and II
Static imaging may or may not be diagnostic

47
Q

What are the aims of medical mangement for hiatal hernias

Give examples of treatments to achieve this?

A

Reduction of gastric acid
- H2 receptor antagonists
- Proton pump inhibitors

Mucosal protection
- Sucralfate (give 2 hrs after antacids)

Increase gastric emptying
- Low fat good?
- Cisapride

Augment lower oesophageal sphincter tone
- Metoclopramide

(Treat secondary aspiration pneumonia)

50% respond in 30 days if acquired
No congenital cases responded
Px good with medical management

48
Q

Surgical treatment for hiatal hernias

A

1) Correct underlying disease prior to correction of hiatus if acquired (BOAS, Lar Par)

2) Combined surgery including
- Phrenoplasty
- Oesophagopexy
- Left fundic gastropexy

49
Q

Describe the technique for repair of hiatal hernia

A

Considerations
- Transect the left hepatic triangular ligament to retract the liver to the right
- Place Orogastric tube to identify oesophagus/hiatus
- Avoid vagal trunks and oesophageal vessels
- Ventilation and evacuation of pneumothorax required post op

Phrenoplasty Technique:
* With or without Incision of phrenicoesophageal ligament circumferentially
* Reduce the size of the hiatal opening
* Place 2/0 Monofilament nylon Horizontal mattress sutures dorsal and ventral through crura

Oesophagopexy technique:
* 3cm partial thickness incision in left oesophagus
* Seromuscular incision in left diaprhagm
* Apposed with 2/0 or 3/0 Monofilament

Left fundic gastropexy
* Anchor fundus to body wall or left sided tube gastropexy

50
Q

What 3 factors may increase the risk of gastroesophageal intussusception?

A
  • Abnormal oesophageal motility (megaoesophagus)
  • Active retrograde motility during vomiting
  • Laxity of the hiatus
51
Q

Common Signalment factors for cases presenting with Gastroesophageal Intussusception?

A

75% are < 3 months old

> 50% are GSDs
(Suspected secondary to congenital megaoesophagus)

52
Q

What radiographic findings can be expected with gastroesophageal intussusception

A

Soft tissue mass within the caudal oesophagus
Lack of gastric axis within the abdomen
Dilated cranial oesophagus
Aspiration pneumonia

53
Q

Treatment options for gastroesophageal intussusception

A

Stabilise
- Manage aspiration
- Supplemental O2
- Volume resuscitation

Minimally invasive
- Oesophagoscopy to faciliate gastric replacement
- PEG tube placement

Surgical
- Ventral midline coeliotomy
- Reduced with gentle traction
- Left fundic gastopexy +/- right gastropexy
- Splenectomy if indicated

Long term
- Manage oesophageal dysmotility disorder

54
Q

Which breeds are predisposed to hypertrophic pyloric gastropathy?

AKA Pyloric stenosis

A

Congenital (Pyloric stenosis)
- Brachys
- Tends to be muscular

Acquired
- Small breeds < 10 kg
- Shih tzus, maltese, lhasa apso
- Male > Females
- Can me muscular with or without mucosal component

55
Q

What is the pathophysiology of hypertrophic pyloric gastropathy in dogs with BOAS?

A

Chornic gas dilation of the stomach due to aerophagia
Increased gastric pressure increases gastrin and gastric acid secretion
This triggers cholecystokinin and secretin production which have a trophic effect on the antral and pyloric mucosa

56
Q

How can pyloric stenosis be diagnosed?

A
  • Retention of food contents > 8 hours
  • Gastric dilation with abrupt narrowing at pyloris on contrast
  • Increased thickness of pyloric layering on US
  • Enlarged mucosal folds visible on endoscopy
57
Q

Treatment for pyloric stenosis

A

Muscular =
* Pyloromyotomy (Fredet Ramstedt)

Mucosal and muscular
* Heineke-Mikulickz pyloroplasty
* Y-U plyoroplasty
(Biopsy and resect mucosa/submucosa)
* Bilroth I

Good-excellent prognosis

58
Q

In what % of cases is endoscopic retrieval of gastric foreign bodies unsuccessful?

How successful was emesis when indicated?

A

~30%

55% successful

59
Q

Name 5 causes of gastric ulceration

A

Hepatic disease
Renal disease
NSAIDs
Corticosteroids
Neoplasia

60
Q

What is the pathophysiology of hepatic and renal disease and gastric ulceration?

A

Hepatic = Reduced degredation of gastrin and histamine => Increased acid secretion
Also portal hypertension => Thrombosis of gastric vessels => Ischemic necrosis

Renal = Reduced clearance of gastrin => Hypergastrinaema

61
Q

What is the pathophysiology of gastric ulceration secondary to NSAIDs

A

Arachidonic acid pathway
Blocks production of PG (PFE mostly) consituitively produced by COX-1
Reduces mucosal blood flow, mucus and bicarb and increases gastric acid production

NSAIDs are also weakly acidic and lipid soluble
which causes topical irritation of the mucosa

62
Q

How do glucocorticoids cause gastric ulceration?

A

Reduce mucus production
Reduce cell turnover
(Mostly pyloric)

63
Q

Medical management for Gastric ucleration

A

H2 receptor antagonists
- Cimetidine
- Ranitidine (also prokinetic)
- Famotidine

Proton Pump Inhibitors (Bind H+/K+ ATPase pump)
- Omeprazole
- Pantoprazole
- Concern for bacterial overgrowth when given > 30 days

Sucralfate
- Dissociated in acid and polymerised into thick paste => biologic band aid
- Binds electrostatically to charged proteins in ulcer bed
- Stimulates PG release => Protective

Misoprostol
- Synthetic PGE analogue
- Increases bicarb and mucous production
- Increases mucosal blood flow
- Reduces H+ secretion by reducing cAMP which reduces H+/K+ ATPase pump activity

Cimetidine and inhibits cytochrome p450 can when adminstering with other drugs.

PPIs are metabilised by c P450

64
Q

Surgical treatment of gastric ulcers

A
  • Full thickness biopsy
  • Partial gastrectomy
  • Bilroth I
  • Serosal patch
65
Q

What are the most common gastric tumour in dogs and cats?

A

Dogs = Gastric adenocarcinoma

Cats = Lymphosarcoma

66
Q

Name a fungal infection which may mimic signs of gastric neoplasia

A

Pythium insidiosum

(Aquatic oomyocota - USA)

Causes severe, inflammatory, infiltrative lesions
May impact gastric outflow

67
Q

Which breeds of dog are predisposed to gastric ACA?

What % have mets at presentation?

Which regions of the stomach tend to be affected?

Name an interesting diffuse presentation of this disease?

MST?

A

Breeds = Belgian shepherds, rough collies, staffies

Mets = 70-80%
(LN, Lungs, liver, testes)

Antrum and lesser curvature most commonly affected

Diffuse infiltative form = LINTIS PLASTICA
Non-distensible, thick, rigid stomach
(Can also present as ulcerative plaques or discrete masseS)

MST = 33 days

68
Q

How is leiomyosarcoma differentiated from GIST?

A

GIST = C-Kit positive

GIST are from Cajal cells

No difference in survival times

69
Q

Is Gastric lymhoma associated with FeLV in cats?

A

NO!!

Solitary or systemic forms
Px depends on grade
MST ~700 d with chemo (CHOP/COP)

Gastric lymphoma in dogs is desperately bad = MST 17 days

70
Q

Name 4 causes of gastric performation?

Non traumatic

A

NSAIDs
Neoplasia
Gastrinoma
Mastocytosis

Tx = En bloc excision, 2 cm margins for neoplasia, LN biopsies, exlap, close routinely.

71
Q

Name 12 risk factors for GDV

A

Pure breed
Large and giant breed
Increased thoracic depth: width ratio
Relative with GDV
Fewer meals per day
Rapid eating
Agressive/fearful temperament
Reduced food particle size
Increased hepatogastric ligament length
Stress or exercise after eating
Splenectomy
Gastric FB

72
Q

Which radiographic position is diagnostic for GDV

A

Right lateral radiograph

Popeye signs
Double bubble

73
Q

In addition to the stomach position, what should be assessed for on radiographs?

A

Pneumoperitoneum

(Suggestive of gastric perforation and necrosis)

74
Q

Review the pathophysiology of GDV

A
75
Q

Which laboratory test is prognostic in GDV?

What can it predict based on which cut offs?

A

**Lactate**

< 6.0 mmol/l
- 99% survival rate

> 6.0 mmol/l
- 88% sens/61% spec for gastric necrosis

>7.4 mmol/l
- 82% accurate for necrosis
- 88% accurate for outcome

Absolute changes in lactate
Negative prognosis if…
- Post treatment lactate > 6.4
- Absolute change of. < 4
- % change < 42.5 %

76
Q

Give an example of a GA protocol for GDV

A

Pre-oxygenation
Premed - Hypomorphine and Diazepatm
Induction - Propofol or etomidate
Antiarrhythmogenic - Lidocaine
Analgesia - Fentanyl-lidocaine CRI (MAC reduction)

Etomidate maintains cardiac output

77
Q

What % GDV rotation is most common?

A

180-270°

78
Q

Which region of the stomach is more commonly affected by necrosis?

A

Greater curvature
(Fundus and Body)

79
Q

Give 2 justifications for prophylactic gastropexy

A

Risk of developing GDV is 4-37% for at risk breeds

Prophylactic gastropexy reduces mortality rate by 29 times

80
Q

Which gastropexy technique is justified for prophylactic treatment?

A

No difference between lap assisted, belt loop, circumcostal or incisional in terms of strength

Minilap approach has similar strength to exlap appraoch

Lap assissted is significantly faster (28 mins) than total lap

Staples are weaker at 7 but not 30 days

Lap assisted is quick, equally strong and less invasive than open

81
Q

What are the main complications following GDV?

A

Septic peritonitis
* Secondary to gastric necrosis
* Revision surgery required

Disseminated intravascular coagulopathy
* Plasma transfusion
* Heparin therapy

Ileus
* Prokinetic (Metoclop or cisapride)
* Intermittent decompression via NG tube

Vomiting
* Centrally acting antiemetic
* Rule out gastric necrosis/peritonitis

Gastric ulceration
* H2-Receptor blocker (Famoditine/Ranititine)
* Proton Pump Inhibitor (Omeprazole/Pantoprazole)

82
Q

What is the reported recurrence rate following GDV treated with gastropexy??

A

4%

4-28 months post op

83
Q

What is the reported survival rate following surgical treatment for GDV?

A

75-90%

84
Q

Name 9 Negative prognostic indicators
(Excluding lactate)

A

Duration of signs > 6 hours
Presence of hypotension
Presence of gastric necrosis
Preop cardiac arrhythmias
Concurrent gastrectomy/splenectomy
Peritonitis
Sepsis
DIC
Elevated myoglobin levels